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Literature DB >> 728285

Simultaneous analysis of dapsone and monoacetyldapsone employing high performance liquid chromatography: a rapid method for determination of acetylator phenotype.

K Carr, J A Oates, A S Nies, R L Woosley.

Abstract

1 A rapid, accurate and convenient technique for determination of acetylator phenotype of patients or subjects has not been available for routine clinical application. 2 An improved method for rapid and convenient determination of acetylator phenotype is described. 3 The plasma concentrations of dapsone (DDS) and monoacetyldapsone (MAD) were measured 3 h after a single oral 100 mg dose of dapsone using a specific and sensitive high performance liquid chromatographic assay. 4 The plasma concentration ratio of monoacetyldapsone to dapsone can accurately assess acetylator phenotype in patients or subjects. 5 The clinical applications for this method are discussed.

Entities: Chemical Species

Mesh：

Substances：
Dapsone

Year: 1978 PMID： 728285 PMCID： PMC1429553 DOI： 10.1111/j.1365-2125.1978.tb04606.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

28 in total

1. Acetylation polymorphism of sulfapyridine in patients with ulcerative colitis and Crohn's disease.

Authors: K M Das; M A Eastwood
Journal: Clin Pharmacol Ther Date: 1975-11 Impact factor: 6.875

2. Hydralazine elimination in man.

Authors: M M Reidenberg; D Drayer; A L DeMarco; C T Bello
Journal: Clin Pharmacol Ther Date: 1973 Nov-Dec Impact factor: 6.875

3. Enzymatic N-acetylation of carcinogenic aromatic amines by liver cytosol of species displaying different organ susceptibilities.

Authors: G M Lower; G T Bryan
Journal: Biochem Pharmacol Date: 1973-07-01 Impact factor: 5.858

4. Relationship of acetyl transferase activity to antinuclear antibodies and toxic symptoms in hypertensive patients treated with hydralazine.

Authors: H M Perry; E M Tan; S Carmody; A Sakamoto
Journal: J Lab Clin Med Date: 1970-07

5. A chromatographic-fluorometric procedure for the determination of nanogram quantities of antileprotic sulfones.

Authors: J F Murray; G R Gordon; J H Peters
Journal: J Lab Clin Med Date: 1971-09

6. Relation of hydralazine plasma concentration to dosage and hypotensive action.

Authors: R Zacest; J Koch-Weser
Journal: Clin Pharmacol Ther Date: 1972 May-Jun Impact factor: 6.875

7. Polymorphic acetylation procainamide in man.

Authors: M M Reidenberg; D E Drayer; M Levy; H Warner
Journal: Clin Pharmacol Ther Date: 1975-06 Impact factor: 6.875

8. Antiarrhythmic potency of N-acetylprocainamide.

Authors: J Elson; J M Strong; W K Lee; A J Atkinson
Journal: Clin Pharmacol Ther Date: 1975-02 Impact factor: 6.875

9. Isoniazid acetylation rate and development of antinuclear antibodies upon isoniazid treatment.

Authors: D Alarcón-Segovia; E Fishbein; H Alcalá
Journal: Arthritis Rheum Date: 1971 Nov-Dec

10. The haemolytic effects of diaphenylsulfone (DDS) in normal subjects and in those with glucose-6-phosphate-dehydrogenase deficiency.

Authors: R L Degowin; R B Eppes; R D Powell; P E Carson
Journal: Bull World Health Organ Date: 1966 Impact factor: 9.408

25 in total

Simultaneous analysis of dapsone and monoacetyldapsone employing high performance liquid chromatography: a rapid method for determination of acetylator phenotype.

1. Acetylation polymorphism of sulfapyridine in patients with ulcerative colitis and Crohn's disease.

2. Hydralazine elimination in man.

3. Enzymatic N-acetylation of carcinogenic aromatic amines by liver cytosol of species displaying different organ susceptibilities.

4. Relationship of acetyl transferase activity to antinuclear antibodies and toxic symptoms in hypertensive patients treated with hydralazine.

5. A chromatographic-fluorometric procedure for the determination of nanogram quantities of antileprotic sulfones.

6. Relation of hydralazine plasma concentration to dosage and hypotensive action.

7. Polymorphic acetylation procainamide in man.

8. Antiarrhythmic potency of N-acetylprocainamide.

9. Isoniazid acetylation rate and development of antinuclear antibodies upon isoniazid treatment.

10. The haemolytic effects of diaphenylsulfone (DDS) in normal subjects and in those with glucose-6-phosphate-dehydrogenase deficiency.

1. Hydralazine dose-response curve analysis.

Review 2. Assessment of liver metabolic function. Clinical implications.

3. A simple method for determining acetylator phenotype using isoniazid.

4. Influence of age, sex and body weight on the dapsone acetylation phenotype.

5. Plasma and salivary pharmacokinetics of dapsone estimated by a thin layer chromatographic method.

6. Methylene dianiline: assessment of exposure and cancer morbidity in power generator workers.

Review 7. Clinical pharmacokinetics of dapsone.

8. N-acetylation phenotyping with dapsone in a mainland Chinese population.

9. A simple test for acetylator phenotype using caffeine.

10. A rapid method for determination of acetylation phenotype using dapsone.