Literature DB >> 7281482

Morphology of foci of altered hepatocytes and naturally-occurring hepatocellular tumors in F344 rats.

J M Ward.   

Abstract

The morphology of liver tumors of F344 rats used as controls in carcinogenesis bioassays were studied. Foci of cellular alteration composed of hepatocytes with basophilic cytoplasm were found commonly in F344 rats, 2 years of age. Eosinophilic and vacuolated foci were considerably less common. The morphology of 67 nodular hepatic lesions indicated that 54 were neoplastic nodules and 13 hepatocellular carcinomas. The majority of these tumors were composed of basophilic hepatocytes. Some of the carcinomas appeared to arise within neoplastic nodules. No tumors metastasized.

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Year:  1981        PMID： 7281482     DOI： 10.1007/BF00496563

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histol        ISSN： 0340-1227


  10 in total

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Journal:  J Natl Cancer Inst       Date:  1980-01       Impact factor: 13.506

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Journal:  Toxicol Appl Pharmacol       Date:  1979-04       Impact factor: 4.219

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Journal:  J Natl Cancer Inst       Date:  1979-11       Impact factor: 13.506

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Journal:  Cancer Lett       Date:  1980-06       Impact factor: 8.679

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Journal:  J Natl Cancer Inst       Date:  1980-11       Impact factor: 13.506
  10 in total
  8 in total

1.  Localized hepatocarcinogenesis: the response of the liver and kidney to implanted carcinogens.

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Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

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Journal:  Am J Pathol       Date:  1991-11       Impact factor: 4.307

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Journal:  Environ Health Perspect       Date:  1985-05       Impact factor: 9.031

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Journal:  Jpn J Cancer Res       Date:  1988-07

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Journal:  Jpn J Cancer Res       Date:  1988-01
  8 in total

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