Literature DB >> 7280442

Clinical studies of pneumococcal vaccines in infants. II. Efficacy and effect on nasopharyngeal carriage.

P F Wright, S H Sell, W K Vaughn, C Andrews, K B McConnell, G Schiffman.   

Abstract

Two polyvalent pneumococcal polysaccharide vaccines were evaluated in about 200 infants. Vaccination did not affect nasopharyngeal carriage of pneumococci nor was titer of type-specific antibody, as determined by radioimmunoassay, predictive of subsequent carriage of individual types. Otitis media occurred with equal frequency in vaccinated and in control children. One of four episodes of documented pneumococcal bacteremia occurred after vaccination and was caused by a type contained in the vaccine. No indication of either an efficacious or detrimental effect of pneumococcal polysaccharide vaccines administered to infants was seen in this study.

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Year:  1981        PMID： 7280442     DOI： 10.1093/clinids/3.supplement_1.s108

Source DB:  PubMed          Journal:  Rev Infect Dis        ISSN： 0162-0886


  6 in total

1.  Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster.

Authors:  F M Russell; J R Carapetis; C Satzke; L Tikoduadua; L Waqatakirewa; R Chandra; A Seduadua; S Oftadeh; Y B Cheung; G L Gilbert; E K Mulholland
Journal:  Clin Vaccine Immunol       Date:  2010-10-13

2.  Age- and serogroup-related differences in observed durations of nasopharyngeal carriage of penicillin-resistant pneumococci.

Authors:  Liselotte Högberg; Patricia Geli; Håkan Ringberg; Eva Melander; Marc Lipsitch; Karl Ekdahl
Journal:  J Clin Microbiol       Date:  2007-01-03       Impact factor: 5.948

3.  Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide.

Authors:  J C Paton; R A Lock; C J Lee; J P Li; A M Berry; T J Mitchell; P W Andrew; D Hansman; G J Boulnois
Journal:  Infect Immun       Date:  1991-07       Impact factor: 3.441

4.  Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children.

Authors:  T Smith; D Lehmann; J Montgomery; M Gratten; I D Riley; M P Alpers
Journal:  Epidemiol Infect       Date:  1993-08       Impact factor: 2.451

5.  Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine in infancy.

Authors:  F M Russell; P V Licciardi; A Balloch; V Biaukula; L Tikoduadua; J R Carapetis; J Nelson; A W J Jenney; L Waqatakirewa; S Colquhoun; Y B Cheung; M L K Tang; E K Mulholland
Journal:  Vaccine       Date:  2010-03-01       Impact factor: 3.641

6.  Long-term impact of pneumococcal polysaccharide vaccination on nasopharyngeal carriage in children previously vaccinated with various pneumococcal conjugate vaccine regimes.

Authors:  Laura K Boelsen; Eileen M Dunne; Karen E Lamb; Kathryn Bright; Yin Bun Cheung; Lisi Tikoduadua; Fiona M Russell; E Kim Mulholland; Paul V Licciardi; Catherine Satzke
Journal:  Vaccine       Date:  2015-07-29       Impact factor: 3.641
  6 in total

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