| Literature DB >> 20199764 |
F M Russell1, P V Licciardi, A Balloch, V Biaukula, L Tikoduadua, J R Carapetis, J Nelson, A W J Jenney, L Waqatakirewa, S Colquhoun, Y B Cheung, M L K Tang, E K Mulholland.
Abstract
Fijian infants aged 6 weeks were stratified by ethnicity and randomized to receive 0, 1, 2, or 3 PCV-7 doses with or without the 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months. Strong booster effects for all 7 PCV-7 serotypes were elicited, and for 4/7 serotypes these responses were highest in the single PCV-7 group. There were fourfold rises in GMC for all non-PCV-7 serotypes. By 17 months the PPV-23 group still had significantly higher GMC (each p<0.001) for all serotypes. The PPV-23 was well tolerated and induced excellent responses for all serotypes which were greatest in the single PCV-7 group. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID: 20199764 PMCID: PMC2857918 DOI: 10.1016/j.vaccine.2010.02.065
Source DB: PubMed Journal: Vaccine ISSN: 0264-410X Impact factor: 3.641