Literature DB >> 72795

The fatty acid composition of sphingomyelin from adult human cerebral white matter and changes in childhood, senium and unspecific brain damage.

R Heipertz, H Pilz, W Scholz.   

Abstract

A micromethod for the investigation of the fatty acid composition of sphingomyelin in presented. In the cerebral white matter of 17 normal adult brains, analyzed for reference, the predominant fatty acids are C 18:0 and C 24:1. Our results are in agreement with those of other authors. Short chained fatty acids are relatively increased in young children; this shift is typical of "immature" myelin. Similar changes are described here in old persons and cases of non-specific brain damage associated with demyelination (autolysis, chronic uremia, juvenile chorea). Sphingomyelin fatty acid composition can be considered a sensitive measure of both disturbed myelination and demyelination.

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Year:  1977        PMID： 72795     DOI： 10.1007/BF00312817

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  13 in total

1.  [DETERMINATION OF C18- AND C24-SPHINGOMYELIN BY THIN-LAYER CHROMATOGRAPHY IN NORMAL AND PATHOLOGICAL BRAINS, INCLUDING A CASE OF NIEMANN-PICK DISEASE].

Authors:  H PILZ; H JATZKEWITZ
Journal:  J Neurochem       Date:  1964-08       Impact factor: 5.372

2.  FATTY ACID COMPOSITION OF HUMAN BRAIN SPHINGOMYELINS: NORMAL VARIATION WITH AGE AND CHANGES DURING MYELIN DISORDERS.

Authors:  S STAELLBERG-STENHAGEN; L SVENNERHOLM
Journal:  J Lipid Res       Date:  1965-01       Impact factor: 5.922

3.  Effects of chronic alcohol abuse on the fatty acid composition of major lipids in the human brain. Hepatocerebral degeneration II.

Authors:  P Lesch; E Schmidt; F W Schmidt
Journal:  Z Klin Chem Klin Biochem       Date:  1973-04

4.  Lipid composition in gray and white matter of the brain in Menkes' disease.

Authors:  H C Lou; G K Holmer; E Reske-Nielsen; P Vagn-Hansen
Journal:  J Neurochem       Date:  1974-03       Impact factor: 5.372

5.  Myelin in multiple sclerosis. Composition of myelin from normal-appearing white matter.

Authors:  K Suzuki; S Kamoshita; Y Eto; W W Tourtellotte; J O Gonatas
Journal:  Arch Neurol       Date:  1973-05

6.  Brain lipids of a case of juvenile Niemann-Pick disease.

Authors:  H B Tjiong; P N Seng; H Debuch; H R Wiedemann
Journal:  J Neurochem       Date:  1973-12       Impact factor: 5.372

7.  [The brain lipids from one-year-old children].

Authors:  P Lesch; K Bernhard
Journal:  Helv Chim Acta       Date:  1967-05-31       Impact factor: 2.164

8.  Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin.

Authors:  J S O'Brien; E L Sampson
Journal:  J Lipid Res       Date:  1965-10       Impact factor: 5.922

9.  The fatty acid composition of major glycosphingolipids (cerebrosides and sulfatides) in human cerebral white matter measured by a simple micromethod.

Authors:  R Heipertz; H Pilz; W Scholz
Journal:  J Neurol       Date:  1976-07-15       Impact factor: 4.849

10.  The distribution of lipids in the human nervous system. IV. Fatty acid composition of major sphingolipids of human infant brain.

Authors:  L Svennerholm; M T Vanier
Journal:  Brain Res       Date:  1973-06-15       Impact factor: 3.252
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  6 in total

Review 1.  Secondary alterations of sphingolipid metabolism in lysosomal storage diseases.

Authors:  Alessandro Prinetti; Simona Prioni; Elena Chiricozzi; Edward H Schuchman; Vanna Chigorno; Sandro Sonnino
Journal:  Neurochem Res       Date:  2011-01-05       Impact factor: 3.996

2.  Potential serum biomarkers from a metabolomics study of autism.

Authors:  Han Wang; Shuang Liang; Maoqing Wang; Jingquan Gao; Caihong Sun; Jia Wang; Wei Xia; Shiying Wu; Susan J Sumner; Fengyu Zhang; Changhao Sun; Lijie Wu
Journal:  J Psychiatry Neurosci       Date:  2016-01       Impact factor: 6.186

Review 3.  Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders.

Authors:  Marco Piccinini; Federica Scandroglio; Simona Prioni; Barbara Buccinnà; Nicoletta Loberto; Massimo Aureli; Vanna Chigorno; Elisa Lupino; Giovanni DeMarco; Annarosa Lomartire; Maria Teresa Rinaudo; Sandro Sonnino; Alessandro Prinetti
Journal:  Mol Neurobiol       Date:  2010-02-03       Impact factor: 5.590

4.  Cerebrospinal fluid lipids in demyelinating disease. I. Sphingolipids.

Authors:  D Seidel; R Buck; R Heipertz; H Pilz
Journal:  J Neurol       Date:  1980-01       Impact factor: 4.849

5.  Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington's disease peripheral blood samples.

Authors:  Anastasios Mastrokolias; Rene Pool; Eleni Mina; Kristina M Hettne; Erik van Duijn; Roos C van der Mast; GertJan van Ommen; Peter A C 't Hoen; Cornelia Prehn; Jerzy Adamski; Willeke van Roon-Mom
Journal:  Metabolomics       Date:  2016-07-27       Impact factor: 4.290

6.  Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.

Authors:  Maxmore Chaibva; Xiang Gao; Pranav Jain; Warren A Campbell; Shelli L Frey; Justin Legleiter
Journal:  ACS Omega       Date:  2018-01-10
  6 in total

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