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Literature DB >> 6153704

Cerebrospinal fluid lipids in demyelinating disease. I. Sphingolipids.

Abstract

The lipid composition of CSF, serum and lymphocytes from patients without demyelinating disease (controls) as well as from patients with acute and chronic MS is analyzed. Individual lipid fractions are isolated by TLC and their fatty acid composition determined. Lipid and fatty acid composition of normal CSF resembles the results found in lymphocytes and it is deduced that CSF lipids are derived mainly from lymphocytes rather than white matter (myelin) or serum. There is an increase of CSF sphingomyelin in patients with acute MS (showing pleocytosis) which is apparently derived from disintegrated lymphocytes; there is also an increase of linoleic acid concentration which could come from serum because of dysfunction of the blood-brain barrier. The role of the CNS in contributing to CSF lipids is considered negligible both in controls and in patients with demyelination.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Fatty Acids
Sphingolipids

Year: 1980 PMID： 6153704 DOI： 10.1007/BF00313115

Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849

11 in total

9. The fatty acid composition of major glycosphingolipids (cerebrosides and sulfatides) in human cerebral white matter measured by a simple micromethod.

Authors: R Heipertz; H Pilz; W Scholz
Journal: J Neurol Date: 1976-07-15 Impact factor: 4.849

10. The fatty acid composition of sphingomyelin from adult human cerebral white matter and changes in childhood, senium and unspecific brain damage.

Authors: R Heipertz; H Pilz; W Scholz
Journal: J Neurol Date: 1977-08-18 Impact factor: 4.849

2 in total

1. Cerebrospinal fluid lipids in demyelinating disease. II. Linoleic acid as an index of impaired blood-CSF barrier.

Authors: D Seidel; R Heipertz; B Weisner
Journal: J Neurol Date: 1980-01 Impact factor: 4.849

2. Relapsing-Remitting Multiple Sclerosis diagnosis from cerebrospinal fluids via Fourier transform infrared spectroscopy coupled with multivariate analysis.

Authors: Dilek Yonar; Levent Ocek; Bedile Irem Tiftikcioglu; Yasar Zorlu; Feride Severcan
Journal: Sci Rep Date: 2018-01-18 Impact factor: 4.379

2 in total

Cerebrospinal fluid lipids in demyelinating disease. I. Sphingolipids.

1. [A NEW METHOD FOR THE QUANTITATIVE ULTRAMICRODETERMINATION OF SPHINGOLIPIDS FROM THE BRAIN].

2. A simple method for the isolation and purification of total lipides from animal tissues.

3. In vivo studies on the metabolism of [15,16-3H]tetracosanoic acid (lignoceric acid) in adult rat brain.

4. Lipids in cerebrospinal fluid. XII. In multiple sclerosis and retrobulbar neuritis.

5. Cerebroside and other polar lipids of the cerebrospinal fluid in neurological diseases.

6. [Studies on the correlation between cerebrospinal fluid lipids and serum lipids].

7. Lipids and proteins in multiple sclerosis white matter.

8. Separation and identification of cerebrosides in cerebrospina fluid by gas chromatography--mas spectrometry.

9. The fatty acid composition of major glycosphingolipids (cerebrosides and sulfatides) in human cerebral white matter measured by a simple micromethod.

10. The fatty acid composition of sphingomyelin from adult human cerebral white matter and changes in childhood, senium and unspecific brain damage.

1. Cerebrospinal fluid lipids in demyelinating disease. II. Linoleic acid as an index of impaired blood-CSF barrier.

2. Relapsing-Remitting Multiple Sclerosis diagnosis from cerebrospinal fluids via Fourier transform infrared spectroscopy coupled with multivariate analysis.