Literature DB >> 7277257

In vivo and in vitro localization of Leishmania within macrophage phagolysosomes: use of colloidal gold as a lysosomal label.

J D Berman, T B Fioretti, D M Dwyer.   

Abstract

The interaction of Leishmania with lysosomes within macrophages in vivo has been investigated. Lysosomes labeled with colloidal gold in vivo fused with phagocytic vacuoles containing Leishmania amastigotes within the macrophages of infected footpad tissue of BALB/c mice. This localization of Leishmania within macrophage phagolysosomes in vivo is the first confirmation for any obligate intracellulaire protozoon that parasite-lysosome interactions in vitro occur in vivo.

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Year:  1981        PMID： 7277257     DOI： 10.1111/j.1550-7408.1981.tb02839.x

Source DB:  PubMed          Journal:  J Protozool        ISSN： 0022-3921


  7 in total

1.  Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.

Authors:  E C Torres-Santos; J M Rodrigues; D L Moreira; M A Kaplan; B Rossi-Bergmann
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

2.  Synthesis of antimony complexes of yeast mannan and mannan derivatives and their effect on Leishmania-infected macrophages.

Authors:  G Cantos; C L Barbieri; M Iacomini; P A Gorin; L R Travassos
Journal:  Biochem J       Date:  1993-01-01       Impact factor: 3.857

3.  Fusion between Leishmania amazonensis and Leishmania major parasitophorous vacuoles: live imaging of coinfected macrophages.

Authors:  Fernando Real; Renato A Mortara; Michel Rabinovitch
Journal:  PLoS Negl Trop Dis       Date:  2010-12-07

4.  The diverse and dynamic nature of Leishmania parasitophorous vacuoles studied by multidimensional imaging.

Authors:  Fernando Real; Renato A Mortara
Journal:  PLoS Negl Trop Dis       Date:  2012-02-14

5.  The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes.

Authors:  M A Horwitz
Journal:  J Exp Med       Date:  1983-12-01       Impact factor: 14.307

6.  Transfer of zymosan (yeast cell walls) to the parasitophorous vacuoles of macrophages infected with Leishmania amazonensis.

Authors:  P S Veras; C de Chastellier; M Rabinovitch
Journal:  J Exp Med       Date:  1992-09-01       Impact factor: 14.307

7.  Receptor-mediated entry of beta-glucuronidase into the parasitophorous vacuoles of macrophages infected with Leishmania mexicana amazonensis.

Authors:  V L Shepherd; P D Stahl; P Bernd; M Rabinovitch
Journal:  J Exp Med       Date:  1983-05-01       Impact factor: 14.307
  7 in total

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