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Literature DB >> 7277208

Kinetics of drug displacement interactions.

Abstract

A simple model simulating the kinetics of drugs displacement kinetics is investigated. It is demonstrated that for highly bound, lowly cleared drugs, displacement interactions are transitory. Consequently, the kinetics of the interaction have to be considered as well as the in vitro interaction. It is possible to have a significant in vitro displacement interaction with no in vivo counterpart. Methods of moderating drug displacement by adjusting the rate and the timing of administration of the displacing agent are discussed.

Mesh：

Year: 1981 PMID： 7277208 DOI： 10.1007/BF01068081

Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN： 0090-466X

8 in total

1. SULPHAPHENAZOLE-INDUCED HYPOGLYCAEMIC ATTACKS IN TOLBUTAMIDE-TREATED DIABETICS.

Authors: L K CHRISTENSEN; J M HANSEN; M KRISTENSEN
Journal: Lancet Date: 1963-12-21 Impact factor: 79.321

2. Impact of aspirin and chlorthalidone on the pharmacodynamics of oral anticoagulant drugs in man.

Authors: R A O'Reilly; M A Sahud; P M Aggeler
Journal: Ann N Y Acad Sci Date: 1971-07-06 Impact factor: 5.691

3. Drug displacement from protein binding: isolation of a redistributional drug interaction in vivo.

Authors: E G McQueen; W M Wardell
Journal: Br J Pharmacol Date: 1971-10 Impact factor: 8.739

4. Warfarin-phenylbutazone interaction in man: a long term multiple dose study.

Authors: W L Schary; R J Lewis; M Rowland
Journal: Res Commun Chem Pathol Pharmacol Date: 1975-04

5. Representation and interpretation of drug displacement interactions.

Authors: W L Schary; L J Aarons; M Rowland
Journal: Biochem Pharmacol Date: 1978-01-01 Impact factor: 5.858

6. The effect of various drugs on the binding of warfarin-14C to human albumin.

Authors: H M Solomon; J J Schrogie
Journal: Biochem Pharmacol Date: 1967-07-07 Impact factor: 5.858

7. Potentiation of anticoagulant effect of warfarin by phenylbutazone.

Authors: P M Aggeler; R A O'Reilly; L Leong; P E Kowitz
Journal: N Engl J Med Date: 1967-03-02 Impact factor: 91.245

8. Effect of sulfisoxazole on pharmacokinetics of free and plasma protein-bound bilirubin in experimental unconjugated hyperbilirubinemia.

Authors: S Oie; G Levy
Journal: J Pharm Sci Date: 1979-01 Impact factor: 3.534

8 in total

Review 8. Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs.

Authors: J H Lin; D M Cocchetto; D E Duggan
Journal: Clin Pharmacokinet Date: 1987-06 Impact factor: 6.447

8 in total

Kinetics of drug displacement interactions.

1. SULPHAPHENAZOLE-INDUCED HYPOGLYCAEMIC ATTACKS IN TOLBUTAMIDE-TREATED DIABETICS.

2. Impact of aspirin and chlorthalidone on the pharmacodynamics of oral anticoagulant drugs in man.

3. Drug displacement from protein binding: isolation of a redistributional drug interaction in vivo.

4. Warfarin-phenylbutazone interaction in man: a long term multiple dose study.

5. Representation and interpretation of drug displacement interactions.

6. The effect of various drugs on the binding of warfarin-14C to human albumin.

7. Potentiation of anticoagulant effect of warfarin by phenylbutazone.

8. Effect of sulfisoxazole on pharmacokinetics of free and plasma protein-bound bilirubin in experimental unconjugated hyperbilirubinemia.

Review 1. Protein binding drug displacement interactions fact or fiction?

Review 2. What is the true clinical significance of plasma protein binding displacement interactions?

3. Serum protein binding of nonsteroidal antiinflammatory drugs: a comparative study.

Review 4. Plasma protein binding displacement interactions--why are they still regarded as clinically important?

5. Beta-Lactamase Gene Expression Level of Hospital-Acquired CRAB Isolated from Children in Picu.

6. Ceftriaxone--bilirubin-albumin interactions in the neonate: an in vivo study.

7. Phenylbutazone-warfarin interaction in man: further stereochemical and metabolic considerations.

Review 8. Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs.