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Literature DB >> 5158200

Drug displacement from protein binding: isolation of a redistributional drug interaction in vivo.

Abstract

1. The pharmacokinetic interaction between phenylbutazone and sulphadoxine has been studied in live sheep.2. Intravenous injection of phenylbutazone causes a rapid fall in the concentration of total sulphadoxine together with a simultaneous rise in the concentration of free sulphadoxine in plasma. Both processes are complete within 3 min of the injection of phenylbutazone.3. These reciprocal changes in the concentrations of total and free sulphadoxine in plasma do not depend on changes in the absorption, hepatic metabolism or renal excretion of sulphadoxine. By exclusion therefore, it is concluded that the effect of phenylbutazone in this interaction is solely to cause redistribution of the sulphadoxine.

Entities: Chemical Disease Species

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Year: 1971 PMID： 5158200 PMCID： PMC1665900

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

12 in total

1. A drug-induced change in the distribution and renal excretion of sulfonamides.

Authors: A H ANTON
Journal: J Pharmacol Exp Ther Date: 1961-12 Impact factor: 4.030

Review 2. The binding of drugs by plasma proteins.

Authors: M C Meyer; D E Guttman
Journal: J Pharm Sci Date: 1968-06 Impact factor: 3.534

3. The binding of three penicillins in the plasma of several mammalian species as studied by ultrafiltration at body temperature.

Authors: P M Keen
Journal: Br J Pharmacol Chemother Date: 1965-10

4. The binding of antibiotics to serum proteins.

Authors: G N Rolinson; R Sutherland
Journal: Br J Pharmacol Chemother Date: 1965-12

Review 5. Progress in sulfonamide research.

Authors: T Struller
Journal: Prog Drug Res Date: 1968

6. Displacement from protein binding of sulphormethoxine by phenylbutazone using in vivo dialysis in rats.

Authors: E G McQueen
Journal: Br J Pharmacol Date: 1969-05 Impact factor: 8.739

7. Displacement of one drug by another from carrier or receptor sites.

Authors: B B Brodie
Journal: Proc R Soc Med Date: 1965-11

8. Enzyme stimulation and inhibition in the metabolism of drugs.

Authors: J J Burns; A H Conney
Journal: Proc R Soc Med Date: 1965-11

9. [Physicochemical and biological studies on sulfonamides. 1. Pharmacologically interesting physicochemical characteristics of 21 sulfonamides and 6 sulfonamide metabolites].

Authors: J RIEDER
Journal: Arzneimittelforschung Date: 1963-02

4. Potential pitfalls in the conventional pharmacokinetic studies: effects of the initial mixing of drug in blood and the pulmonary first-pass elimination.

Authors: W L Chiou
Journal: J Pharmacokinet Biopharm Date: 1979-10

Drug displacement from protein binding: isolation of a redistributional drug interaction in vivo.

1. A drug-induced change in the distribution and renal excretion of sulfonamides.

Review 2. The binding of drugs by plasma proteins.

3. The binding of three penicillins in the plasma of several mammalian species as studied by ultrafiltration at body temperature.

4. The binding of antibiotics to serum proteins.

Review 5. Progress in sulfonamide research.

6. Displacement from protein binding of sulphormethoxine by phenylbutazone using in vivo dialysis in rats.

7. Displacement of one drug by another from carrier or receptor sites.

8. Enzyme stimulation and inhibition in the metabolism of drugs.

9. [Physicochemical and biological studies on sulfonamides. 1. Pharmacologically interesting physicochemical characteristics of 21 sulfonamides and 6 sulfonamide metabolites].

10. Drug displacement from protein binding: source of the sulphadoxine liberated by phenylbutazone.

1. Valproic acid and warfarin: an underrecognized drug interaction.

Review 2. Protein binding drug displacement interactions fact or fiction?

3. Effect of heparin administration on plasma binding of benzodiazepines.

4. Potential pitfalls in the conventional pharmacokinetic studies: effects of the initial mixing of drug in blood and the pulmonary first-pass elimination.

Review 5. Plasma concentrations in the control of drug therapy.

6. Kinetics of drug displacement interactions.

Review 7. Drug interactions and clinical pharmacokinetics.

8. Drug displacement from protein binding: source of the sulphadoxine liberated by phenylbutazone.