Literature DB >> 7275815

Studies on neplanocin A, new antitumor antibiotic. I. Producing organism, isolation and characterization.

S Yaginuma, N Muto, M Tsujino, Y Sudate, M Hayashi, M Otani.   

Abstract

Neplanocin A. C11H13N5O3, is a novel carbocyclic analog of adenosine with cyclopentene. It was isolated from the culture filtrate of Ampullariella regularis A11079 by means of ion-exchange, carbon, silica gel adsorption, or partition chromatography. Neplanocin A forms crystals, and is stable at acidic or alkaline pH. Neplanocin A has cytotoxicity against L5178Y cells in culture and showed a remarkable effect on the life prolongation of mice infected with L1210 leukemia.

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Year:  1981        PMID： 7275815     DOI： 10.7164/antibiotics.34.359

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  16 in total

1.  Coordinated Biosynthesis of the Purine Nucleoside Antibiotics Aristeromycin and Coformycin in Actinomycetes.

Authors:  Gudan Xu; Liyuan Kong; Rong Gong; Liudong Xu; Yaojie Gao; Ming Jiang; You-Sheng Cai; Kui Hong; Youcai Hu; Peng Liu; Zixin Deng; Neil P J Price; Wenqing Chen
Journal:  Appl Environ Microbiol       Date:  2018-10-30       Impact factor: 4.792

Review 2.  Dynamic kinetic resolution of Vince lactam catalyzed by γ-lactamases: a mini-review.

Authors:  Shaozhou Zhu; Guojun Zheng
Journal:  J Ind Microbiol Biotechnol       Date:  2018-10-23       Impact factor: 3.346

3.  Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach.

Authors:  Jong Hyun Cho; Franck Amblard; Steven J Coats; Raymond F Schinazi
Journal:  J Org Chem       Date:  2012-12-26       Impact factor: 4.354

4.  9-(trans-2',trans-3'-Dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity.

Authors:  M Hasobe; J G McKee; D R Borcherding; R T Borchardt
Journal:  Antimicrob Agents Chemother       Date:  1987-11       Impact factor: 5.191

5.  Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.

Authors:  Sylvester L Mosley; Brian A Bakke; Joshua M Sadler; Naresh K Sunkara; Kathleen M Dorgan; Zhaohui Sunny Zhou; Katherine L Seley-Radtke
Journal:  Bioorg Med Chem       Date:  2006-08-10       Impact factor: 3.641

6.  Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action.

Authors:  Masaaki Toyama; Koichi Watashi; Masanori Ikeda; Atsuya Yamashita; Mika Okamoto; Kohji Moriishi; Masamichi Muramatsu; Takaji Wakita; Ashoke Sharon; Masanori Baba
Journal:  Antimicrob Agents Chemother       Date:  2022-05-23       Impact factor: 5.938

7.  Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.

Authors:  Hyo-Joong Kim; Ashoke Sharon; Chandralata Bal; Jianing Wang; Madhan Allu; Zhuhui Huang; Michael G Murray; Leda Bassit; Raymond F Schinazi; Brent Korba; Chung K Chu
Journal:  J Med Chem       Date:  2009-01-08       Impact factor: 7.446

8.  Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.

Authors:  Manchi C M Reddy; Gokulan Kuppan; Nishant D Shetty; Joshua L Owen; Thomas R Ioerger; James C Sacchettini
Journal:  Protein Sci       Date:  2008-09-24       Impact factor: 6.725

9.  Diastereoselective synthesis of a spironoraristeromycin using an acylnitroso Diels-Alder reaction.

Authors:  Weimin Lin; Kristopher G Virga; Kyung-Hee Kim; Jaroslav Zajicek; David Mendel; Marvin J Miller
Journal:  J Org Chem       Date:  2009-08-21       Impact factor: 4.354

10.  Antiviral and antimetabolic activities of neplanocins.

Authors:  E De Clercq
Journal:  Antimicrob Agents Chemother       Date:  1985-07       Impact factor: 5.191
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