Literature DB >> 7274657

Genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for multiple loci and localization of Ahd-2 on chromosome 19.

G P Timms, R S Holmes.   

Abstract

Electrophoretic and activity variation of the cytoplasmic isozyme of aldehyde dehydrogenase (designated AHD-B4) was observed among inbred strains and Harwell linkage-testing stocks of Mus musculus. The phenotypes are inherited in a normal Mendelian fashion, with two alleles showing co-dominant expression at a single locus (Ahd-2). The locus was shown to segregate independently of Ahd-1 (encoding the mitochondrial AHD-A2 isozymes on chromosome 4; HOLMES 1978). Linkage data of Ahd-2 with ep (pale ears), ru (ruby eyes) and bm (brachymorphic) suggest that it is localized near the centromeric end of chromosome 19. Electrophoretic evidence for a third AHD isozyme (designated AHD-Cy), which is predominantly localized in the liver microsomal fraction, is also presented.

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Year:  1981        PMID： 7274657      PMCID： PMC1214396     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  9 in total

1.  The subcellular localization of aldehyde dehydrogenase in rat liver.

Authors:  A A Horton; M C Barrett
Journal:  Arch Biochem Biophys       Date:  1975-04       Impact factor: 4.013

2.  Different forms of rat liver aldehyde dehydrogenase and their subcellular distribution.

Authors:  T Koivula; M Koivusalo
Journal:  Biochim Biophys Acta       Date:  1975-07-27

3.  Role of liver cytosolic aldehyde dehydrogenase isozymes in control of blood acetaldehyde concentrations.

Authors:  D R Petersen; A C Collins; R A Deitrich
Journal:  J Pharmacol Exp Ther       Date:  1977-05       Impact factor: 4.030

4.  Chromosome 19 of the house mouse.

Authors:  P W Lane; E M Eicher; J L Southard
Journal:  J Hered       Date:  1974 Sep-Oct       Impact factor: 2.645

5.  Genetic influence upon phenobarbital-induced increase in rat liver supernatant aldehyde dehydrogenase activity.

Authors:  R A Deitrich; A C Collins; V G Erwin
Journal:  J Biol Chem       Date:  1972-11-25       Impact factor: 5.157

6.  Racial differences in alcohol sensitivity: a new hypothesis.

Authors:  H W Goedde; S Harada; D P Agarwal
Journal:  Hum Genet       Date:  1979-10-02       Impact factor: 4.132

7.  Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.

Authors:  N J Greenfield; R Pietruszko
Journal:  Biochim Biophys Acta       Date:  1977-07-08

8.  Horse liver aldehyde dehydrogenase. Purification and characterization of two isozymes.

Authors:  J Eckfeldt; L Mope; K Takio; T Yonetani
Journal:  J Biol Chem       Date:  1976-01-10       Impact factor: 5.157

9.  Purification and immunochemical characterization of aldehyde dehydrogenase from 2-acetylaminofluorene-induced rat hepatomas.

Authors:  R Lindahl; R N Feinstein
Journal:  Biochim Biophys Acta       Date:  1976-12-08
  9 in total
  10 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 2.  Mouse chromosome 19.

Authors:  J L Guénet
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 3.  Mouse map of paralogous genes.

Authors:  J H Nadeau; M Kosowsky
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 4.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

5.  Chromosomal assignment of the genes for human aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2.

Authors:  L C Hsu; A Yoshida; T Mohandas
Journal:  Am J Hum Genet       Date:  1986-05       Impact factor: 11.025

6.  Genetics and ontogeny of aldehyde dehydrogenase isozymes in th mouse: evidence for a locus controlling the inducibility of the liver microsomal isozyme.

Authors:  G P Timms; R S Holmes
Journal:  Biochem Genet       Date:  1981-12       Impact factor: 1.890

7.  Biochemical genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for stomach- and testis-specific isozymes.

Authors:  P B Mather; R S Holmes
Journal:  Biochem Genet       Date:  1984-12       Impact factor: 1.890

8.  Aldehyde dehydrogenase (ALDH) isozymes in the gray short-tailed opossum (Monodelphis domestica): tissue and subcellular distribution and biochemical genetics of ALDH3.

Authors:  R S Holmes; R A van Oorschot; J L VandeBerg
Journal:  Biochem Genet       Date:  1991-04       Impact factor: 1.890

9.  Genetics of ocular NAD+-dependent alcohol dehydrogenase and aldehyde dehydrogenase in the mouse: evidence for genetic identity with stomach isozymes and localization of Ahd-4 on chromosome 11 near trembler.

Authors:  R S Holmes; R A Popp; J L VandeBerg
Journal:  Biochem Genet       Date:  1988-04       Impact factor: 1.890

10.  Enzyme markers in inbred rat strains: genetics of new markers and strain profiles.

Authors:  M Adams; P R Baverstock; C H Watts; G A Gutman
Journal:  Biochem Genet       Date:  1984-08       Impact factor: 1.890
  10 in total

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