| Literature DB >> 7274295 |
P J Aggett, H T Delves, J M Thorn, D J Atherton, J T Harris, A D Bangham.
Abstract
A nine year-old girl with acrodermatitis enteropathica developed typical clinical and biochemical features of zinc deficiency on two occasions while on an oral zinc supplement. On both occasions, these features responded immediately when she was treated with amphotericin B lozenges. Studies in vitro showed that amphotericin increases the permeability to zinc of pure lipid membranes containing cholesterol. We suggest that the antibiotic enhanced zinc absorption from the oral supplement thereby effecting resolution of the patient's zinc deficiency.Entities:
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Year: 1981 PMID： 7274295 DOI： 10.1007/BF00441164
Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183