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Literature DB >> 7274184

Metal-induced infidelity of DNA synthesis.

Abstract

In this paper, we consider the effects of metal ions on the accuracy of catalysis by DNA polymerases. Certain activating and nonactivating metal ions have been shown to diminish the fidelity of DNA synthesis in vitro with a variety of DNA polymerases. There is a significant correlation between the metals that decrease fidelity and those that have been reported to be mutagenic and carcinogenic. Thus, metal carcinogens are no exception to the general postulate that carcinogens can be identified by their interactions with DNA.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1981 PMID： 7274184 PMCID： PMC1568814 DOI： 10.1289/ehp.8140197

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

31 in total

1. Escherichia coli deoxyribonucleic acid polymerase I, a zinc metalloenzyme. Nuclear quadrupolar relaxation studies of the role of bound zinc.

Authors: C F Springgate; A S Mildvan; R Abramson; J L Engle; L A Loeb
Journal: J Biol Chem Date: 1973-09-10 Impact factor: 5.157

2. Nuclear deoxyribonucleic acid polymerase. Purification and properties of the homogeneous enzyme from human KB cells.

Authors: T S Wang; W D Sedwick; D Korn
Journal: J Biol Chem Date: 1974-02-10 Impact factor: 5.157

3. The mechanism of Escherichia coli deoxyribonucleic acid polymerase I. Magnetic resonance and kinetic studies of the role of metals.

Authors: J P Slater; I Tamir; L A Loeb; A S Mildvan
Journal: J Biol Chem Date: 1972-11-10 Impact factor: 5.157

4. Comparative rates of spontaneous mutation.

Authors: J W Drake
Journal: Nature Date: 1969-03-22 Impact factor: 49.962

5. The infidelity of avian myeloblastosis virus deoxyribonucleic acid polymerase in polynucleotide replication.

Authors: N Battula; L A Loeb
Journal: J Biol Chem Date: 1974-07-10 Impact factor: 5.157

6. Low molecular weight deoxyribonucleic acid polymerase from calf thymus chromatin. II. Initiation and fidelity of homopolymer replication.

Authors: L M Chang
Journal: J Biol Chem Date: 1973-10-25 Impact factor: 5.157

7. An in vitro transversion by a mutationally altered T4-induced DNA polymerase.

Authors: Z W Hall; I R Lehman
Journal: J Mol Biol Date: 1968-09-28 Impact factor: 5.469

8. Interaction of metal ions with polynucleotides and related compounds. XII. The relative effect of various metal ions on DNA helicity.

Authors: G L Eichhorn; Y A Shin
Journal: J Am Chem Soc Date: 1968-12-18 Impact factor: 15.419

Review 9. Mechanism of enzyme action.

Authors: A S Mildvan
Journal: Annu Rev Biochem Date: 1974 Impact factor: 23.643

10. Zinc in DNA polymerases.

Authors: J P Slater; A S Mildvan; L A Loeb
Journal: Biochem Biophys Res Commun Date: 1971-07-02 Impact factor: 3.575

15 in total

1. Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/primer or by perturbing the polymerase reaction.

Authors: Yinbo Zhang; Andrey G Baranovskiy; Emin T Tahirov; Tahir H Tahirov; Youri I Pavlov
Journal: DNA Repair (Amst) Date: 2016-05-12

2. Novel MntR-independent mechanism of manganese homeostasis in Escherichia coli by the ribosome-associated protein HflX.

Authors: Gursharan Kaur; Sandeepan Sengupta; Vineet Kumar; Aruna Kumari; Aditi Ghosh; Pradeep Parrack; Dipak Dutta
Journal: J Bacteriol Date: 2014-05-02 Impact factor: 3.490

3. In vitro assessment of the toxicity of metal compounds : IV. Disposition of metals in cells: Interactions with membranes, glutathione, metallothionein, and DNA.

Authors: N T Christie; M Costa
Journal: Biol Trace Elem Res Date: 1984-04 Impact factor: 3.738

Review 10. The carcinogenicity of beryllium.

Authors: M Kuschner
Journal: Environ Health Perspect Date: 1981-08 Impact factor: 9.031