Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Preferential involvement of chromosome 1q in a primary breast carcinoma.

Literature DB >> 7272991

Preferential involvement of chromosome 1q in a primary breast carcinoma.

Abstract

The cytogenetic findings by G- and C-banding in a primary breast carcinoma are reported. The tumor is characterized by a high modal number of chromosomes (79) and 14 markers of ten different origins. Chromosome #1 is more frequently involved in structural and numerical aberrations than is any other chromosome; nine copies of 1q were present in each cell examined. This observation supports the hypothesis that duplication of chromosome 1q may play an important role in the progression of malignant tumors.

Entities: Disease

Mesh：

Year: 1981 PMID： 7272991 DOI： 10.1016/0165-4608(81)90066-2

Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608

Keyword Cloud
Cited

6 in total

1. Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment.

Authors: S W Lee; C Tomasetto; K Swisshelm; K Keyomarsi; R Sager
Journal: Proc Natl Acad Sci U S A Date: 1992-03-15 Impact factor: 11.205

Preferential involvement of chromosome 1q in a primary breast carcinoma.

1. Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment.

2. Breast cancer genetic evolution: I. Data from cytogenetics and DNA content.

Review 3. Cytogenetic and molecular biologic alterations in human breast cancer: a review.

4. Detection of 1q polysomy in interphase nuclei of human solid tumors with a biotinylated probe.

Review 5. Karyotypic progression in human tumors.

Review 6. Small metacentric marker chromosomes, particularly isochromosomes, in cancer.