| Literature DB >> 2539324 |
E Viegas-Péquignot1, M Jeanpierre, A M Dutrillaux, M Gerbault-Seureau, M Muleris, B Dutrillaux.
Abstract
A biotinylated probe (L23-21) specific for the 1q12 band of human karyotype was used to detect the 1q segment in interphase nuclei of breast and colon carcinomas. This probe was selected because trisomy or polysomy 1q is the most frequent chromosomal change observed in solid tumors. This method enables cancerous cells, including near-diploid ones carrying an unbalanced rearrangement of 1q, to be easily identified.Entities:
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Year: 1989 PMID: 2539324 DOI: 10.1007/bf00283681
Source DB: PubMed Journal: Hum Genet ISSN: 0340-6717 Impact factor: 4.132