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Literature DB >> 7272228

Idiopathic myelofibrosis: a possible role for immune-complexes in the pathogenesis of bone marrow fibrosis.

F C Cappio, R Vigliani, A Novarino, G Camussi, D Campana, F Gavosto.

Abstract

Sixteen patients with idiopathic myelofibrosis (IM) have been investigated with respect to the possibility that immune mechanisms may be of importance in the pathogenesis of bone marrow fibrosis. The following points appear relevant: (1) immune-complexes (IC) are detectable with different techniques in a high percentage of patients with IM. Their presence is associated with evidence of bone-marrow histological markers of immune activity. (2) IgG is the main Ig class in the composition of IM IC. The results obtained favour the hypothesis that autoimmune mechanisms are involved in IM patients.

Entities: Disease Species

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Year: 1981 PMID： 7272228 DOI： 10.1111/j.1365-2141.1981.tb07192.x

Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998

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Cited

14 in total

1. Familial cutaneous vasculopathy of German shepherds: clinical, genetic and preliminary pathological and immunological studies.

Authors: J A Weir; J A Yager; J L Caswell; W M Parker; I B Johnstone; P K Basrur; C Emms
Journal: Can Vet J Date: 1994-12 Impact factor: 1.008

2. Systemic lupus erythematosus and bone marrow necrosis in a dog.

Authors: L M Felchle; L A McPhee; M E Kerr; D M Houston
Journal: Can Vet J Date: 1996-12 Impact factor: 1.008

3. Circulating high molecular weight IgG fibronectin complexes in myeloproliferative disorders.

Authors: T P Baglin; S M Price; B J Boughton
Journal: J Clin Pathol Date: 1990-02 Impact factor: 3.411

4. Histomorphometry of bone marrow biopsies in primary osteomyelofibrosis/-sclerosis (agnogenic myeloid metaplasia)--correlations between clinical and morphological features.

Authors: J Thiele; B Hoeppner; R Zankovich; R Fischer
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1989

5. Lymphocyte subpopulations in peripheral blood and bone marrow in patients with idiopathic myelofibrosis.

Authors: E Vellenga; S Poppema; C G Kallenberg; M R Halie
Journal: Blut Date: 1987-08

Review 6. An immune dysregulation in MPN.

Authors: Giovanni Barosi
Journal: Curr Hematol Malig Rep Date: 2014-12 Impact factor: 3.952

Idiopathic myelofibrosis: a possible role for immune-complexes in the pathogenesis of bone marrow fibrosis.

1. Familial cutaneous vasculopathy of German shepherds: clinical, genetic and preliminary pathological and immunological studies.

2. Systemic lupus erythematosus and bone marrow necrosis in a dog.

3. Circulating high molecular weight IgG fibronectin complexes in myeloproliferative disorders.

4. Histomorphometry of bone marrow biopsies in primary osteomyelofibrosis/-sclerosis (agnogenic myeloid metaplasia)--correlations between clinical and morphological features.

5. Lymphocyte subpopulations in peripheral blood and bone marrow in patients with idiopathic myelofibrosis.

Review 6. An immune dysregulation in MPN.

7. Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias.

8. Immunohistochemical evaluation of bone marrow lymphoid nodules in chronic myeloproliferative disorders.

9. Composition of immune complexes and their relation to plasma fibronectin in chronic myeloproliferative disorders.

10. Autoimmune Myelofibrosis in Systemic Lupus Erythematosus Report of Two Cases and Review of the Literature.