Literature DB >> 1949608

Immunohistochemical evaluation of bone marrow lymphoid nodules in chronic myeloproliferative disorders.

V Franco1, A M Florena, F Aragona, G Campesi.   

Abstract

One hundred and seventy bone marrow biopsies from patients with chronic myeloproliferative disorders (CMPDs) were evaluated for the presence of lymphoid nodules (LNs) and were immunostained using a panel of monoclonal antibodies (UCHL1, 4KB5 and L26) recognizing different lymphocyte antigens. LNs were found in 35% of cases of idiopathic thrombocythaemia, 24.6% of myelofibrosis/osteomyelosclerosis, 18.2% of polycythaemia vera 12.1% of chronic myeloid leukaemia and 19.2% of borderline cases. Varying degrees of immunohistochemical positivity for the three antibodies tested were found. LNs were always made up of variable proportions of both T- and B-lymphocytes with a prevalence of T-cells. This latter observation suggests that bone marrow LNs in CMPDs could be an expression of reactivity.

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Year:  1991        PMID： 1949608     DOI： 10.1007/bf01606516

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  42 in total

1.  Alpha-smooth muscle actin is expressed in a subset of bone marrow stromal cells in normal and pathological conditions.

Authors:  A Schmitt-Gräff; O Skalli; G Gabbiani
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1989

2.  Lymphoid nodules of bone marrow: normal and abnormal.

Authors:  A M Rywlin; R S Ortega; C J Dominguez
Journal:  Blood       Date:  1974-03       Impact factor: 22.113

3.  Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.

Authors:  J R Clark; M E Williams; S H Swerdlow
Journal:  Am J Clin Pathol       Date:  1990-01       Impact factor: 2.493

4.  Glycol methacrylate (GMA) embedding for light microscopy. II. Immunohistochemical analysis of semithin sections of undecalcified marrow cores.

Authors:  A Islam; E Archimbaud; E S Henderson; T Han
Journal:  J Clin Pathol       Date:  1988-08       Impact factor: 3.411

5.  Acute myeloid leukemia: immunohistologic findings in paraffin-embedded bone marrow biopsy specimens.

Authors:  H P Horny; M Campbell; B Steinke; E Kaiserling
Journal:  Hum Pathol       Date:  1990-06       Impact factor: 3.466

6.  Paraffin section immunohistochemistry. I. Non-Hodgkin's lymphoma.

Authors:  P A Hall; A J d'Ardenne; A G Stansfeld
Journal:  Histopathology       Date:  1988-08       Impact factor: 5.087

7.  [Bone marrow lymphoid follicles in myelofibrosis compared with chronic myelogenous leukaemia (author's transl)].

Authors:  L Hernandez Nieto; M Morey Sureda; A Granena; E Montserrat Costa; E Feliu; C Rozman
Journal:  Nouv Rev Fr Hematol       Date:  1979

8.  Immunologic abnormalities in myelofibrosis with activation of the complement system.

Authors:  B R Gordon; M Coleman; P Kohen; N K Day
Journal:  Blood       Date:  1981-11       Impact factor: 22.113

9.  The immunophenotyping of extramedullary myeloid cell tumors in paraffin-embedded tissue sections.

Authors:  F R Davey; S Olson; A S Kurec; R Eastman-Abaya; A J Gottlieb; D Y Mason
Journal:  Am J Surg Pathol       Date:  1988-09       Impact factor: 6.394

Review 10.  Chronic myeloproliferative disorders (CMPD).

Authors:  R Burkhardt; R Bartl; K Jäger; B Frisch; G Kettner; G Mahl; M Sund
Journal:  Pathol Res Pract       Date:  1984-11       Impact factor: 3.250
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  1 in total

1.  Focal lymphoid aggregates (nodules) in bone marrow biopsies: differentiation between benign hyperplasia and malignant lymphoma--a practical guideline.

Authors:  J Thiele; T K Zirbes; H M Kvasnicka; R Fischer
Journal:  J Clin Pathol       Date:  1999-04       Impact factor: 3.411
  1 in total

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