| Literature DB >> 7267134 |
M De Castro Costa, P De Sutter, J Gybels, J Van Hees.
Abstract
Adjuvant-induced arthritic rats were observed clinically and behaviorally. The clinical disease has a duration of greater than 1 month and can be divided into a pre-clinical (1-10 days), an acute (15-30 days), postacute (30-50 days) and a late phase (greater than 50 days). Adjuvant arthritis induces significantly quantitatively changes in the rats' behaviour. Two types of behavioural change merit special attention: freezing (arresting) and scratching. Freezing is significantly increased in the acute and postacute phases; it is increased by morphine, this effect being blocked by naloxone. Scratching is significantly increased in the acute, postacute and late phases; it is decreased by morphine, this effect being blocked by naloxone. The chronic presence of scratching, and the effects of morphine and naloxone on it, allow us to consider it as a possible pain-rated behaviour and therefore as a possible parameter for the study of chronic pain in animals.Entities:
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Year: 1981 PMID： 7267134 DOI： 10.1016/0304-3959(81)90193-7
Source DB: PubMed Journal: Pain ISSN： 0304-3959 Impact factor: 6.961