Literature DB >> 7263820

Simple high-performance liquid chromatographic method for the analysis of 9-(2-hydroxyethoxymethyl)guanine (acyclovir) in human plasma and urine.

G Land, A Bye.   

Abstract

Acyclovir, a new antiviral drug for human use, could not be solvent extracted and was retained poorly by reversed-phase (RP) columns. Drug in urine and plasma (deproteinised) could be chromatographed successfully as an ion-pair (with heptanesulphonic acid) on RP-18 columns. The validated method had the required sensitivity for a wide variety of clinical situations including metabolic and pharmacokinetic studies.

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Year:  1981        PMID： 7263820     DOI： 10.1016/s0378-4347(00)80137-1

Source DB:  PubMed          Journal:  J Chromatogr


  10 in total

1.  [Oral prophylaxis of herpes infections using acyclovir following bone marrow transplantation: a clinical and clinico-pharmacological study].

Authors:  G Ehninger; A Vallbracht; K Schüch; I Kumbier; R Dopfer; H Schmidt; P Ostendorf
Journal:  Klin Wochenschr       Date:  1986-06-16

2.  The physicochemical properties, plasma enzymatic hydrolysis, and nasal absorption of acyclovir and its 2'-ester prodrugs.

Authors:  Z Shao; G B Park; R Krishnamoorthy; A K Mitra
Journal:  Pharm Res       Date:  1994-02       Impact factor: 4.200

3.  Bile salt-fatty acid mixed micelles as nasal absorption promoters. III. Effects on nasal transport and enzymatic degradation of acyclovir prodrugs.

Authors:  Z Shao; A K Mitra
Journal:  Pharm Res       Date:  1994-02       Impact factor: 4.200

Review 4.  Clinical pharmacokinetics of acyclovir.

Authors:  O L Laskin
Journal:  Clin Pharmacokinet       Date:  1983 May-Jun       Impact factor: 6.447

5.  Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acid mixed micelles: correlation with facilitated drug transport.

Authors:  Z Shao; A K Mitra
Journal:  Pharm Res       Date:  1992-09       Impact factor: 4.200

6.  Drug binding by reservoirs in elastomeric infusion devices.

Authors:  D R Jenke
Journal:  Pharm Res       Date:  1994-07       Impact factor: 4.200

7.  Determination of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) in biological fluids by reverse-phase high pressure liquid chromatography.

Authors:  E H Wiltink; P Stekkinger; J A Brakenhoff; S A Danner
Journal:  Pharm Weekbl Sci       Date:  1987-10-16

8.  A competitive enzyme-linked immunosorbent assay to quantitate acyclovir and BW B759U in human plasma and urine.

Authors:  S M Tadepalli; R P Quinn; D R Averett
Journal:  Antimicrob Agents Chemother       Date:  1986-01       Impact factor: 5.191

Review 9.  Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.

Authors:  D M Richards; A A Carmine; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1983-11       Impact factor: 9.546

10.  Acyclovir permeation enhancement across intestinal and nasal mucosae by bile salt-acylcarnitine mixed micelles.

Authors:  G B Park; Z Shao; A K Mitra
Journal:  Pharm Res       Date:  1992-10       Impact factor: 4.200
  10 in total

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