Literature DB >> 7262545

Lack of genic variation in the abundant proteins of human kidney.

S C Smith, R R Racine, C H Langley.   

Abstract

Abundant proteins of 25 human kidneys were surveyed for genic variation by means of two-dimensional electrophoresis. Eighty-three (83) proteins were scored, and no genic variation was detected. This reduction in genic heterozygosity corroborates results determined with two-dimensional electrophoresis in mice and flies. These results suggest that previous estimates of electrophoretic variation may have been in error because of biased selection of loci.

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Year:  1980        PMID： 7262545      PMCID： PMC1219311     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  9 in total

1.  Identification and genetic localization of mRNAs from ovarian follicle cells of Drosophila melanogaster.

Authors:  A C Spradling; A P Mahowald
Journal:  Cell       Date:  1979-03       Impact factor: 41.582

2.  Reevaluation of level of genic heterozygosity in natural population of Drosophila melanogaster by two-dimensional electrophoresis.

Authors:  A J Brown; C H Langley
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

3.  Enzyme null alleles in natural populations of Drosophila melanogaster: Frequencies in a North Carolina population.

Authors:  R A Voelker; C H Langley; A J Brown; S Ohnishi; B Dickson; E Montgomery; S C Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

4.  Hidden alleles at the alpha-glycerophosphate dehydrogenase locus in Colias butterflies.

Authors:  G B Johnson
Journal:  Genetics       Date:  1976-05       Impact factor: 4.562

5.  Polymorphism and the subunit structure of enzymes: a contribution to the neutralist-selectionist controversy.

Authors:  H Harris; D A Hopkinson; Y H Edwards
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

6.  Enzyme polymorphisms in man.

Authors:  H Harris
Journal:  Proc R Soc Lond B Biol Sci       Date:  1966-03-22

7.  Genic heterogeneity within electrophoretic "alleles" and the pattern of variation among loci in Drosophila pseudoobscura.

Authors:  R S Singh
Journal:  Genetics       Date:  1979-12       Impact factor: 4.562

8.  Genetic heterogeneity within electrophoretic "alleles" of xanthine dehydrogenase in Drosophila pseudoobscura.

Authors:  R S Singh; R C Lewontin; A A Felton
Journal:  Genetics       Date:  1976-11       Impact factor: 4.562

9.  Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells.

Authors:  R A Steinberg; P H O'Farrell; U Friedrich; P Coffino
Journal:  Cell       Date:  1977-03       Impact factor: 41.582
  9 in total
  14 in total

1.  Environmentally controlled phenotypic plasticity of morphology and polypeptide expression in two populations of Daphnia pulex (Crustacea: cladocera).

Authors:  Lester W Lee
Journal:  Oecologia       Date:  1984-08       Impact factor: 3.225

2.  Average locus differences in mutability related to protein "class": a hypothesis.

Authors:  J V Neel
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

3.  Hubby and Lewontin on Protein Variation in Natural Populations: When Molecular Genetics Came to the Rescue of Population Genetics.

Authors:  Brian Charlesworth; Deborah Charlesworth; Jerry A Coyne; Charles H Langley
Journal:  Genetics       Date:  2016-08       Impact factor: 4.562

4.  Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: V. Genetic polymorphism of cytosol 31k polypeptide.

Authors:  I Kondo; K Yamakawa; M Shibasaki; T Yamamoto; H Hamaguchi
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

Review 5.  A revised estimate of the amount of genetic variation in human proteins: implications for the distribution of DNA polymorphisms.

Authors:  J V Neel
Journal:  Am J Hum Genet       Date:  1984-09       Impact factor: 11.025

6.  Identification of genetic variants in erythrocyte lysate by two-dimensional gel electrophoresis.

Authors:  B B Rosenblum; J V Neel; S M Hanash; J L Joseph; N Yew
Journal:  Am J Hum Genet       Date:  1984-05       Impact factor: 11.025

7.  Null allele frequencies at allozyme loci in natural populations of Drosophila melanogaster.

Authors:  C H Langley; R A Voelker; A J Brown; S Ohnishi; B Dickson; E Montgomery
Journal:  Genetics       Date:  1981-09       Impact factor: 4.562

8.  Genetic variants detected among 106 lymphocyte polypeptides observed in two-dimensional gels.

Authors:  S M Hanash; L J Baier; D Welch; R Kuick; M Galteau
Journal:  Am J Hum Genet       Date:  1986-09       Impact factor: 11.025

9.  Human lymphocyte polymorphisms detected by quantitative two-dimensional electrophoresis.

Authors:  D Goldman; C R Merril
Journal:  Am J Hum Genet       Date:  1983-09       Impact factor: 11.025

10.  Twenty-seven protein polymorphisms by two-dimensional electrophoresis of serum, erythrocytes, and fibroblasts in two pedigrees.

Authors:  D Goldman; L R Goldin; P Rathnagiri; S J O'Brien; J A Egeland; C R Merril
Journal:  Am J Hum Genet       Date:  1985-09       Impact factor: 11.025
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