Literature DB >> 7257951

Evaluation of anti-inflammatory and analgesic properties of L-glutamine.

P Jain, N K Khanna.   

Abstract

It was established that L-glutamine, an aminoacid, has marked anti-inflammatory activity and moderate analgesic activity. The drug was effective orally in suppressing various experimentally induced inflammatory reactions and did not show any gastric irritation in anti-inflammatory doses. It is observed that the anti-inflammatory effect of L-glutamine is not due to counter irritant action. It is suggested that it may partially mediate its anti-inflammatory activity by interfering with the action and/or synthesis of prostaglandins. Its anti-inflammatory activity is comparable to that of phenylbutazone and merits further study.

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Year:  1981        PMID： 7257951     DOI： 10.1007/bf01967621

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  27 in total

1.  ON THE ANTI-INFLAMMATORY ACTIVITY OF PROTAMINE SULPHATE AND OF HEXADIMETHRINE BROMIDE, INHIBITORS OF PLASMA KININ FORMATION.

Authors:  D N KELLETT
Journal:  Br J Pharmacol Chemother       Date:  1965-06

2.  On the mechanism through which hydrocortisone affects the resistance of tissues to injury; an experimental study with the granuloma pouch technique.

Authors:  H SELYE
Journal:  J Am Med Assoc       Date:  1953-07-25

3.  Effect of deoxycortone and ascorbic acid on formaldehyde-induced arthritis in normal and adrenalectomized rats.

Authors:  G BROWNLEE
Journal:  Lancet       Date:  1950-01-28       Impact factor: 79.321

4.  Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine.

Authors:  M Di Rosa; J P Giroud; D A Willoughby
Journal:  J Pathol       Date:  1971-05       Impact factor: 7.996

5.  Screens for anti-inflammatory drugs.

Authors:  M Di Rosa; D A Willoughby
Journal:  J Pharm Pharmacol       Date:  1971-04       Impact factor: 3.765

6.  Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine.

Authors:  C J Niemegeers; F M Lenaerts; P A Janssen
Journal:  Arzneimittelforschung       Date:  1974-10

7.  [Localized edema induced by nystatin as a model of experimental inflammation].

Authors:  P Schiatti; D Selva; E Arrigoni-Martelli
Journal:  Boll Chim Farm       Date:  1970-01

8.  Anti-inflammatory activity of DL-valine.

Authors:  N K Khanna; B R Madan
Journal:  Indian J Exp Biol       Date:  1978-07       Impact factor: 0.818

9.  Effect of creatinine on various experimentally induced inflammatory models.

Authors:  B R Madan; N K Khanna
Journal:  Indian J Physiol Pharmacol       Date:  1979 Jan-Mar

10.  Anti-inflammatory activity of the steroid alkaloid glycoside, toatine.

Authors:  R B Filderman; B A Kovacs
Journal:  Br J Pharmacol       Date:  1969-11       Impact factor: 8.739
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  12 in total

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2.  Glutamine-enriched intravenous feedings attenuate extracellular fluid expansion after a standard stress.

Authors:  M R Scheltinga; L S Young; K Benfell; R L Bye; T R Ziegler; A A Santos; J H Antin; P R Schloerb; D W Wilmore
Journal:  Ann Surg       Date:  1991-10       Impact factor: 12.969

3.  Antiinflammatory activity of methionine, methionine sulfoxide and methionine sulfone.

Authors:  M K Unnikrishnan; M N Rao
Journal:  Agents Actions       Date:  1990-08

4.  Anti-inflammatory effects of muramyl dipeptide in experimental models of acute inflammation.

Authors:  Z Zídek; K Masek; F Sedivý
Journal:  Agents Actions       Date:  1984-01

5.  Glutamine Deprivation Causes Hydrogen Peroxide-induced Interleukin-8 Expression via Jak1/Stat3 Activation in Gastric Epithelial AGS Cells.

Authors:  Yun Mi Lee; Mi Jung Kim; Youngha Kim; Hyeyoung Kim
Journal:  J Cancer Prev       Date:  2015-09

6.  Evaluation of the Anti-Inflammatory, Antioxidant and Immunomodulatory Effects of the Organic Extract of the Red Sea Marine Sponge Xestospongia testudinaria against Carrageenan Induced Rat Paw Inflammation.

Authors:  Nagla A El-Shitany; Lamiaa A Shaala; Aymn T Abbas; Umama A Abdel-Dayem; Esam I Azhar; Soad S Ali; Rob W M van Soest; Diaa T A Youssef
Journal:  PLoS One       Date:  2015-09-30       Impact factor: 3.240

7.  Optimization of medium composition for in vitro shoot proliferation and growth of date palm cv. Mejhoul.

Authors:  Mouaad Amine Mazri; Reda Meziani; Jamal El Fadile; Az-Eddine Ezzinbi
Journal:  3 Biotech       Date:  2016-05-12       Impact factor: 2.406

8.  The Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise.

Authors:  Ali Nemati; Reza Alipanah-Moghadam; Leila Molazadeh; Abbas Naghizadeh Baghi
Journal:  Drug Des Devel Ther       Date:  2019-12-11       Impact factor: 4.162

9.  Combination of Glutamine and Ulinastatin Treatments Greatly Improves Sepsis Outcomes.

Authors:  Junyan Wang; Jiahui Zhou; Shuancheng Bai
Journal:  J Inflamm Res       Date:  2020-02-19

10.  Traditional Chinese medicine Biqi capsule compared with leflunomide in combination with methotrexate in patients with rheumatoid arthritis: a randomized controlled trial.

Authors:  Zhang Wang; Jiaqi Wu; Dongyun Li; Xuan Tang; Yue Zhao; Xiao Cai; Xianghong Chen; Xiumin Chen; Qingchun Huang; Runyue Huang
Journal:  Chin Med       Date:  2020-04-23       Impact factor: 5.455
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