Literature DB >> 7257946

The direct excitatory effects of cimetidine on the smooth muscle of guinea pig ileum.

S Vyas, S C Verma.   

Abstract

1. Cimetidine produced dose-dependent contractions in isolated guinea pig ileum and these responses were not blocked by mepyramine the H1-receptor antagonist. 2. Atropine competitively inhibited the cimetidine-induced contractions in the guinea pig ileum. 3. Cimetidine-induced responses were potentiated in the presence of eserine. Magnesium ions non-competitively inhibited the contractions due to cimetidine. Our findings suggest that cimetidine excites the guinea pig ileum through muscarinic receptors by releasing acetylcholine.

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Year:  1981        PMID： 7257946     DOI： 10.1007/bf01967613

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  11 in total

1.  The nature of the neuromuscular block produced by magnesium.

Authors:  J DEL CASTILLO; L ENGBAEK
Journal:  J Physiol       Date:  1954-05-28       Impact factor: 5.182

2.  A quantitative study of metiamide, a histamine H2-antagonist, on the isolated whole rat stomach.

Authors:  K T Bunce; M E Parsons
Journal:  J Physiol       Date:  1976-06       Impact factor: 5.182

3.  Cimetidine suppression of nocturnal gastric secretion in active duodenal ulcer.

Authors:  G F Longstreth; V L Go; J R Malagelada
Journal:  N Engl J Med       Date:  1976-04-08       Impact factor: 91.245

4.  Phosphorylase, calcium, and cyclic AMP in smooth-muscle contraction.

Authors:  J Diamond
Journal:  Am J Physiol       Date:  1973-10

Review 5.  The link between agonist action and response in smooth muscle.

Authors:  L Hurwitz; A Suria
Journal:  Annu Rev Pharmacol       Date:  1971       Impact factor: 13.820

6.  Receptors mediating some actions of histamine.

Authors:  A S Ash; H O Schild
Journal:  Br J Pharmacol Chemother       Date:  1966-08

7.  A cellular calcium pool for contraction of rabbit ileal muscle.

Authors:  P D Joiner
Journal:  Can J Physiol Pharmacol       Date:  1973-04       Impact factor: 2.273

8.  Healing of gastric ulcer during treatment with cimetidine.

Authors:  R E Pounder; R H Hunt; M Stekelman; G J Milton-Thompson; J J Misiewicz
Journal:  Lancet       Date:  1976-02-14       Impact factor: 79.321

9.  The effect of metiamide on acid secretion stimulated by gastrin, acetylcholine and dibutyryl cyclic adenosine 3',5'-monophosphate in the isolated whole stomach of the rat.

Authors:  K T Bunce; M E Parsons; N A Rollings
Journal:  Br J Pharmacol       Date:  1976-09       Impact factor: 8.739

10.  Cimetidine in the treatment of active duodenal and prepyloric ulcers.

Authors:  G Bodemar; A Walan
Journal:  Lancet       Date:  1976-07-24       Impact factor: 79.321
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