Evaluation of vincristine, CCNU and methyl-CCNU at high level doses in an experimental murine renal adenocarcinoma model.

Balb/C mice were implanted with tumor cells from primary tumor in donor animals bearing renal cell adenocarcinoma. Survival time, tumor growth and metastatic occurrence in treated animals were not significantly improved by high dose Methyl-CCNU, CCNU or Vincristine. It was also concluded that the dose levels of Methyl-CCNU and CCNU used for this study were highly toxic causing early death in the animals. Such studies thus fail to support clinical hopes that these agents would be effective for chemotherapy regimens in human renal tumors.