Literature DB >> 6640825

Development and characterization of a new murine renal tumor model. Chemotherapeutic results.

M Vandendris, P Dumont, R Heimann, G Atassi.   

Abstract

A murine renal cell carcinoma model, the RC tumor, was pharmacologically and histologically characterized and was used for the evaluation of 20 chemotherapeutic agents. This model, when implanted IP or SC showed reproducible behavior and was found to be very sensitive to many drugs with different mechanisms of action, and particularly to alkylating agents. The IP-implanted tumor was sensitive to some clinically active drugs which were reported inactive against L1210 or P388 murine leukemias. The highest sensitivity of this model than of L1210 and P388 leukemias makes the RC tumor a good prescreening system for testing potential chemotherapeutic agents.

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Year:  1983        PMID： 6640825     DOI： 10.1007/BF00254201

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  11 in total

1.  Malignant neoplasms of the kidney; an analysis of 353 patients followed five years or more.

Authors:  R H FLOCKS; M C KADESKY
Journal:  J Urol       Date:  1958-02       Impact factor: 7.450

2.  Evaluation of hexamethylmelamine in murine renal cell carcinoma model.

Authors:  P D Williams; J Burdick; G P Murphy
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1974-02

3.  The effect of hormonal therapy on a transplantable renal cortical adenocarcinoma in syngeneic mice.

Authors:  M S Soloway; G H Myers
Journal:  J Urol       Date:  1973-03       Impact factor: 7.450

4.  A murine renal cell carcinoma.

Authors:  G P Murphy; W J Hrushesky
Journal:  J Natl Cancer Inst       Date:  1973-04       Impact factor: 13.506

5.  Proceedings: Hormone-induced and spontaneous regression of metastatic renal cancer.

Authors:  H J Bloom
Journal:  Cancer       Date:  1973-11       Impact factor: 6.860

6.  Detection of tumor-specific transplantation antigens in a murine renal cortical carcinoma.

Authors:  G H Myers
Journal:  Surg Forum       Date:  1971

7.  The diagnosis and treatment of renal cell carcinoma.

Authors:  J B deKernion; D Berry
Journal:  Cancer       Date:  1980-04-15       Impact factor: 6.860

8.  Evaluation of vincristine, CCNU and methyl-CCNU at high level doses in an experimental murine renal adenocarcinoma model.

Authors:  P D Williams; P Kantor; G P Murphy
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1981-03

9.  HORMONE-DEPENDENT TUMOURS OF THE KIDNEY. I. THE OESTROGEN-INDUCED RENAL TUMOUR OF THE SYRIAN HAMSTER. HORMONE TREATMENT AND POSSIBLE RELATIONSHIP TO CARCINOMA OF THE KIDNEY IN MAN.

Authors:  H J BLOOM; C E DUKES; B C MITCHLEY
Journal:  Br J Cancer       Date:  1963-12       Impact factor: 7.640

10.  The histogenesis of stilboestrol-induced renal tumours in the male golden hamster.

Authors:  E S HORNING; J W WHITTICK
Journal:  Br J Cancer       Date:  1954-09       Impact factor: 7.640
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  3 in total

1.  Investigation of a new murine model of regional lymph node metastasis: characteristics of the model and applications.

Authors:  M Vandendris; P Dumont; P Semal; R Heimann; G Atassi
Journal:  Clin Exp Metastasis       Date:  1985 Jan-Mar       Impact factor: 5.150

2.  Pharmacokinetics and metabolism of hexamethylmelamine in mice bearing renal cell tumors.

Authors:  J Dubois; G Atassi; M Hanocq; F Abikhalil
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

3.  In vivo antitumor activity of sparsomycin and its analogues in eight murine tumor models.

Authors:  Z Zylicz; D J Wagener; H van Rennes; E van der Kleijn; P Lelieveld; L A van den Broek; H C Ottenheijm
Journal:  Invest New Drugs       Date:  1988-12       Impact factor: 3.850
  3 in total

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