Literature DB >> 7248154

Human monoclonal antibodies to lung-cancer antigens.

K Sikora, R Wright.   

Abstract

Lymphocytes obtained from hilar and bronchial lymph nodes from 23 patients undergoing radical surgery for carcinoma of the bronchus were fused with established rat or mouse myeloma lines. 62% of the resultant hybrids were found to be secreting human Ig detected by a sensitive staphylococcal Protein A-coupled SRBC assay. Immunoglobulins synthesized by such hybrids were internally labelled with 3H-lysine and their antibody activity against a variety of membrane preparations determined. Nine monoclonal antibodies were found which bound to molecules on lung-cancer membranes and not on normal lung membranes from the same patient.

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Year:  1981        PMID： 7248154      PMCID： PMC2010695          DOI： 10.1038/bjc.1981.101

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  14 in total

1.  In vitro assays of cell-mediated immunity to human solid tumors: problems of quantitation, specificity, and interpretation.

Authors:  R W Baldwin
Journal:  J Natl Cancer Inst       Date:  1975-10       Impact factor: 13.506

2.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

3.  A buffered chromic chloride method of attaching antigens to red cells: use in haemagglutination.

Authors:  R N Poston
Journal:  J Immunol Methods       Date:  1974-05       Impact factor: 2.303

4.  Delayed-hypersensitivity reactions to soluble membrane antigens of human malignant lung cells.

Authors:  A C Hollinshead; T H Stewart; R B Herberman
Journal:  J Natl Cancer Inst       Date:  1974-02       Impact factor: 13.506

5.  Studies on specificity of cell-mediated immunity to human tumors.

Authors:  M Takasugi; M R Mickey; P I Terasaki
Journal:  J Natl Cancer Inst       Date:  1974-12       Impact factor: 13.506

6.  Cell surface antigens of human melanoma identified by monoclonal antibody.

Authors:  M Y Yeh; I Hellström; J P Brown; G A Warner; J A Hansen; K E Hellström
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

7.  Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

Authors:  M Herlyn; Z Steplewski; D Herlyn; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

8.  Antibody responses of tumor-bearing mice to their own tumors captured and perpetuated as hybridomas.

Authors:  C R Simrell; P A Klein
Journal:  J Immunol       Date:  1979-11       Impact factor: 5.422

9.  Detection in colorectal carcinoma patients of antibody cytotoxic to established cell strains derived from carcinoma of the human colon and rectum.

Authors:  R M Schultz; W A Woods; M A Chirigos
Journal:  Int J Cancer       Date:  1975-07-15       Impact factor: 7.396

10.  Further studies on a human lung tumor-associated antigen. Comparison of antigens from different tumors.

Authors:  S A Gaffar; J A Braatz; K H Kortright; G L Princler; K R McIntire
Journal:  J Biol Chem       Date:  1979-03-25       Impact factor: 5.157
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  13 in total

Review 1.  Human tumor-associated antigens identified by monoclonal antibodies.

Authors:  K E Hellström; I Hellström; J P Brown
Journal:  Springer Semin Immunopathol       Date:  1982

Review 2.  Human monoclonal antibodies.

Authors:  S P Cole; B G Campling; T Atlaw; D Kozbor; J C Roder
Journal:  Mol Cell Biochem       Date:  1984-06       Impact factor: 3.396

3.  UC 729-6, a human lymphoblastoid B-cell line useful for generating antibody-secreting human-human hybridomas.

Authors:  M C Glassy; H H Handley; H Hagiwara; I Royston
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

4.  Monoclonal antibodies in oncology.

Authors:  K Sikora
Journal:  J Clin Pathol       Date:  1982-04       Impact factor: 3.411

Review 5.  Human monoclonal antibodies: methods of production and some aspects of their application in oncology.

Authors:  L Olsson
Journal:  Med Oncol Tumor Pharmacother       Date:  1984

6.  A human-human hybridoma secreting anti-Pseudomonas aeruginosa exotoxin-A monoclonal antibody with highly potent neutralizing activity.

Authors:  M Kuriyama; Y Ichimori; S Iwasa; K Tsukamoto
Journal:  Cytotechnology       Date:  1990-01       Impact factor: 2.040

7.  Biochemical and immunological characterizations of antigens recognised by human monoclonal antibodies.

Authors:  A Imam; C R Taylor
Journal:  Br J Cancer       Date:  1989-06       Impact factor: 7.640

8.  Detection by a human monoclonal antibody of a glycoprotein associated with malignant proliferation of mammary epithelial cells.

Authors:  S A Imam; L A Mills; C R Taylor
Journal:  Br J Cancer       Date:  1991-12       Impact factor: 7.640

9.  Loss of secretion in mouse-human hybrids need not be due to the loss of a structural gene.

Authors:  R L Raison; K Z Walker; C R Halnan; D Briscoe; A Basten
Journal:  J Exp Med       Date:  1982-11-01       Impact factor: 14.307

10.  Monoclonal antibodies against two human lung carcinoma cell lines.

Authors:  D T Brown; M Moore
Journal:  Br J Cancer       Date:  1982-11       Impact factor: 7.640
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