Literature DB >> 7246347

Effect of histamine on the mitogenic response of human lymphocytes and its modification by cimetidine and levamisole.

K Meretey, G Room, R N Maini.   

Abstract

The phytohaemagglutinin (PHA) mitogenic response of human blood lymphocytes demonstrated a dose-dependent inhibition by histamine (in the range 5 X 10(-7) M). Using suboptimal mitogenic doses of PHA the suppression was more pronounced. Stimulation using different doses of pokeweed mitogen (PWM) was not altered by histamine. Purified T cells and a lymphocyte population depleted of histamine-receptor-bearing cells were less sensitive to the histamine effect. In the supernatants of histamine-stimulated cultures, suppressor factor activity was found. Cimetidine could reverse the effect of histamine in a dose-dependent manner. Adding levamisole to the PHA cultures also produced some antihistaminic effect.

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Year:  1981        PMID： 7246347     DOI： 10.1007/bf01991465

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  20 in total

1.  The separation and reactivity in vitro of a subpopulation of human lymphocytes which bind histamine. Correlation of histamine reactivity with cellular maturation.

Authors:  J J Ballet; E Merler
Journal:  Cell Immunol       Date:  1976-06-15       Impact factor: 4.868

2.  Histamine suppression of human lymphocyte responses to mitogens.

Authors:  S R Wang; B Zweiman
Journal:  Cell Immunol       Date:  1978-03-01       Impact factor: 4.868

3.  The role of cyclic 3',5' adenosine monophosphate in the specific cytolytic activity of lymphocytes.

Authors:  C S Henney; H R Bourne; L M Lichtenstein
Journal:  J Immunol       Date:  1972-06       Impact factor: 5.422

4.  Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

5.  Histamine-releasing activity (HRA). I. Production by mitogen- or antigen-stimulated human mononuclear cells.

Authors:  D O Thueson; L S Speck; M A Lett-Brown; J A Grant
Journal:  J Immunol       Date:  1979-08       Impact factor: 5.422

6.  Histamine-induced suppressor factor (HSF): further studies on the nature of the stimulus and the cell which produces it.

Authors:  R E Rocklin; D K Greineder; K L Melmon
Journal:  Cell Immunol       Date:  1979-05       Impact factor: 4.868

7.  Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes.

Authors:  R E Rocklin
Journal:  J Clin Invest       Date:  1976-04       Impact factor: 14.808

8.  Generation of suppressor lymphocytes during sensitization in culture against a syngeneic tumor: affinity chromatography on insolubilized histamine.

Authors:  B Schechter; S Segal; M Feldman
Journal:  J Immunol       Date:  1978-04       Impact factor: 5.422

9.  Con A-inducible suppression of MLC: evidence for mediation by the TH2 + T cell subset in man.

Authors:  E L Reinherz; S F Schlossman
Journal:  J Immunol       Date:  1979-04       Impact factor: 5.422

10.  Histamine-induced suppressor factor (HSF): effect on migration inhibitory factor (MIF) production and proliferation.

Authors:  R E Rocklin
Journal:  J Immunol       Date:  1977-05       Impact factor: 5.422
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  7 in total

1.  Immunization in vitro and production of monoclonal antibodies specific to insoluble and weakly immunogenic proteins.

Authors:  J Van Ness; U K Laemmli; D E Pettijohn
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

2.  Chemiluminescence response of human blood mononuclear cells to PHA and histamine.

Authors:  K Merétey; U Böhm; A Falus
Journal:  Agents Actions       Date:  1983-04

3.  Spontaneous suppressor cell activity in the peripheral blood of patients with malignant and chronic inflammatory bowel diseases.

Authors:  K Doldi; B Manger; B Koch; J Riemann; P Hermanek; J R Kalden
Journal:  Clin Exp Immunol       Date:  1984-03       Impact factor: 4.330

4.  Antimetastatic effect of cimetidine on mice bearing a C3H mouse mammary adenocarcinoma: survival and lymphocyte function studies.

Authors:  M Penhaligon; J Anthoons; D Pilkington; R A Wolstencroft; T Bates; A H Nias
Journal:  Clin Exp Metastasis       Date:  1984 Jan-Mar       Impact factor: 5.150

5.  Immunomodulation of cimetidine in healthy volunteers.

Authors:  N H Brockmeyer; E Kreuzfelder; C Bluhm; G Shen; E Scheiermann; H O Keinecke; E E Ohnhaus
Journal:  Klin Wochenschr       Date:  1989-01-04

6.  The use of molecular probes in the study of the action of histamine on macrophages.

Authors:  K Merétey; A Falus
Journal:  Agents Actions       Date:  1988-04

7.  Inhibition of phytohaemagglutinin-induced proliferation of human peripheral blood lymphocytes by histamine and histamine H1 and H2 agonists.

Authors:  A M Badger; J Young; G Poste
Journal:  Clin Exp Immunol       Date:  1983-01       Impact factor: 4.330
  7 in total

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