Literature DB >> 7245229

Incidence of brain tumors in rats fed aspartame.

H Ishii.   

Abstract

The brain tumorigenicity of aspartame (APM) and of its diketopiperazine (DKP) was studied in 860 SCL Wistar rats. APM at dietary levels of 1 g/kg, 2 gK/, 4 g/kg or APM + DKP (3:1) 4 g/kg was fed for 104 weeks. One atypical astrocytoma was found in a control rat and 2 astrocytomas, 2 oligodendrogliomas and 1 ependymoma were scattered among the 4 test groups. There was no significant difference in the incidence of brain tumors between control and test groups. It is concluded that neither AMP nor DKP caused brain tumors in rats in this study.

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Year:  1981        PMID： 7245229     DOI： 10.1016/0378-4274(81)90089-8

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  10 in total

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Review 9.  Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners.

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Review 10.  Aspartame-True or False? Narrative Review of Safety Analysis of General Use in Products.

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  10 in total

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