Literature DB >> 7241426

Comparison of the effects of atropine and glycopyrrolate on various end-organs.

R K Mirakhur, J W Dundee.   

Abstract

Atropine and glycopyrrolate (glycopyrronium bromide), a quaternary ammonium drug, were evaluated in volunteers following intramuscular administration with respect to effects on various end-organs with cholinergic innervation. Glycopyrrolate appears to be five to six times more potent than atropine in its antisialogogue effect and also exhibits a selective, though prolonged, effect on salivary secretion and sweat gland activity. It has minimal cardiovascular, ocular and central nervous system effects.

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Year:  1980        PMID： 7241426      PMCID： PMC1438092     

Source DB:  PubMed          Journal:  J R Soc Med        ISSN： 0141-0768            Impact factor:   5.344


  13 in total

1.  Atropine, scopolamine, and related compounds.

Authors:  E I EGER
Journal:  Anesthesiology       Date:  1962 May-Jun       Impact factor: 7.892

2.  The methonium.

Authors:  W D M PATON; E ZAIMIS
Journal:  Pharmacol Rev       Date:  1952-09       Impact factor: 25.468

3.  Arrhythmias during halothane anaesthesia II: the influence of atropine.

Authors:  B Eikard; J R Andersen
Journal:  Acta Anaesthesiol Scand       Date:  1977       Impact factor: 2.105

4.  Glycopyrrolate methobromide. 1. Effect on salivary secretion.

Authors:  G M Wyant; E Kao
Journal:  Can Anaesth Soc J       Date:  1974-03

5.  Glycopyrrolate as a substitute for atropine in neostigmine reversal of muscle relaxant drugs.

Authors:  S Ramamurthy; M H Shaker; A P Winnie
Journal:  Can Anaesth Soc J       Date:  1972-07

6.  Comparative study of the effects of oral and i.m. atropine and hyoscine in volunteers.

Authors:  R K Mirakhur
Journal:  Br J Anaesth       Date:  1978-06       Impact factor: 9.166

7.  A comparison of glycopyrrolate and atropine during reversal of nondepolarizing neuromuscular block with neostigmine.

Authors:  G W Ostheimer
Journal:  Anesth Analg       Date:  1977 Mar-Apr       Impact factor: 5.108

8.  Glycopyrrolate-neostigmine mixture for antagonism of neuromuscular block: comparison with atropine-neostigmine mixture.

Authors:  R K Mirakhur; J W Dundee; R S Clarke
Journal:  Br J Anaesth       Date:  1977-08       Impact factor: 9.166

9.  Cardiac dysrhythmias in outpatient dental anaesthesia in children. The effect of prophylactic intravenous atropine.

Authors:  A C Thurlow
Journal:  Anaesthesia       Date:  1972-10       Impact factor: 6.955

10.  Antisialogogue drugs in man; comparison of atropine, scopolamine (1-hyoscine) and 1-hyoscyamine (bellafoline).

Authors:  G M WYANT; A B DOBKIN
Journal:  Anaesthesia       Date:  1957-04       Impact factor: 6.955
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  9 in total

Review 1.  Glycopyrrolate oral solution: for chronic, severe drooling in pediatric patients with neurologic conditions.

Authors:  Karly P Garnock-Jones
Journal:  Paediatr Drugs       Date:  2012-08-01       Impact factor: 3.022

2.  The mydriatic effect of topical glycopyrrolate.

Authors:  D Varssano; S Rothman; K Haas; M Lazar
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-03       Impact factor: 3.117

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Authors:  T Pastrana; H Reineke-Bracke; F Elsner
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4.  Effect of glycopyrrolate and atropine on thermoregulation after exercise.

Authors:  K H Simpson; J H Green; F R Ellis
Journal:  Br J Clin Pharmacol       Date:  1986-11       Impact factor: 4.335

5.  Atropine or glycopyrrolate with neostigmine 5 mg: a comparative dose-response study.

Authors:  M G Salem; R S Ahearn
Journal:  J R Soc Med       Date:  1986-01       Impact factor: 5.344

6.  Is It Time for an Expanded Role of Dexmedetomidine in Contemporary Anesthesia Practice? - A Clinician's Perspective.

Authors:  Christian Bohringer; Hong Liu
Journal:  Transl Perioper Pain Med       Date:  2018-04-12

Review 7.  Vasovagal Reactions during Interventional Pain Management Procedures-A Review of Pathophysiology, Incidence, Risk Factors, Prevention, and Management.

Authors:  Brian Malave; Bruce Vrooman
Journal:  Med Sci (Basel)       Date:  2022-07-25

Review 8.  Sialorrhea in Parkinson's Disease.

Authors:  Jonathan Isaacson; Sanskruti Patel; Yasar Torres-Yaghi; Fernando Pagán
Journal:  Toxins (Basel)       Date:  2020-10-31       Impact factor: 4.546

9.  Prevalence, risk factors, and optimized management of moderate-to-severe thirst in the post-anesthesia care unit.

Authors:  Chia-Wei Lee; Shih-Ting Liu; Ya-Jung Cheng; Ching-Tang Chiu; Yu-Fen Hsu; Anne Chao
Journal:  Sci Rep       Date:  2020-09-30       Impact factor: 4.379
  9 in total

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