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Literature DB >> 723928

Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound.

A H Wang, J Nathans, G van der Marel, J H van Boom, A Rich.

Abstract

The crystal structure of a complex containing deoxy CpG and a terpyridine platinum compound (TPH) shows a DNA double helical fragment with TPH intercalated between two Watson-Crick GC base pairs. The DNA unwinding angle is 23 degrees and the pucker of the deoxyribose rings differ at the 3' and 5' ends.

Entities: Chemical

Mesh：

Substances：

Year: 1978 PMID： 723928 DOI： 10.1038/276471a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

16 in total

Review 1. Metallo-intercalators and metallo-insertors.

Authors: Brian M Zeglis; Valerie C Pierre; Jacqueline K Barton
Journal: Chem Commun (Camb) Date: 2007-09-20 Impact factor: 6.222

2. Interaction of phenylthiolato-(2,2',2"-terpyridine)platinum(II) cation with DNA.

Authors: L P Wakelin; W D McFadyen; A Walpole; I A Roos
Journal: Biochem J Date: 1984-08-15 Impact factor: 3.857

3. The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.

Authors: J L Crawford; F J Kolpak; A H Wang; G J Quigley; J H van Boom; G van der Marel; A Rich
Journal: Proc Natl Acad Sci U S A Date: 1980-07 Impact factor: 11.205

4. Molecular mechanical studies of proflavine and acridine orange intercalation.

Authors: A Dearing; P Weiner; P A Kollman
Journal: Nucleic Acids Res Date: 1981-03-25 Impact factor: 16.971

5. Atomic resolution analysis of a 2:1 complex of CpG and acridine orange.

Authors: A H Wang; G J Quigley; A Rich
Journal: Nucleic Acids Res Date: 1979-08-24 Impact factor: 16.971

6. Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro.

Authors: Engin Ulukaya; Ferda Ari; Konstantinos Dimas; Mehmet Sarimahmut; Emel Guney; Nikos Sakellaridis; Veysel T Yilmaz
Journal: J Cancer Res Clin Oncol Date: 2011-08-02 Impact factor: 4.553

Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound.

Review 1. Metallo-intercalators and metallo-insertors.

2. Interaction of phenylthiolato-(2,2',2"-terpyridine)platinum(II) cation with DNA.

3. The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.

4. Molecular mechanical studies of proflavine and acridine orange intercalation.

5. Atomic resolution analysis of a 2:1 complex of CpG and acridine orange.

6. Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro.

Review 7. The path for metal complexes to a DNA target.

8. The binding of binuclear platinum(II)-terpyridine complexes to DNA.

9. Crystal structure of an RNA.DNA hybrid reveals intermolecular intercalation: dimer formation by base-pair swapping.

10. Binuclear platinum (II)-terpyridine complexes. A new class of bifunctional DNA-intercalating agent.