Literature DB >> 7238853

[New esters of substituted anilinonicotinic and phenylanthranilic acids].

M Los, J E Boned, C Piccinali.   

Abstract

In the search for new non-steroidal antiinflammatory drugs with low ulcerogenic activity, phthalidyl and pivaloyloxymethyl esters of anilinonicotinic and N-phenylanthranilic acids were synthesized. One of them, the 3-phthalidyl ester of 2-([3-(trifluoromethyl)phenyl]amino)-3-pyridinecarboxylic acid, also named talniflumate, showed lower ulcerogenic activity and toxicity and greater antiinflammatory activity than the niflumic acid.

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Year:  1981        PMID: 7238853

Source DB:  PubMed          Journal:  Farmaco Sci        ISSN: 0430-0920


  2 in total

1.  Effect of food on systemic exposure to niflumic acid following postprandial administration of talniflumate.

Authors:  Wonku Kang; Kibum Kim; Eun-Young Kim; Kwang-il Kwon; Jun Seok Bang; Young-Ran Yoon
Journal:  Eur J Clin Pharmacol       Date:  2008-07-08       Impact factor: 2.953

2.  Screening study for genetic polymorphisms affecting pharmacokinetics of talniflumate.

Authors:  Li Hua Jin; Bo-Hyung Kim; Ji Hyun Lee; Kidong Lee; KyuBum Kwack; Sung-Vin Yim
Journal:  Transl Clin Pharmacol       Date:  2017-12-20
  2 in total

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