Literature DB >> 7238585

Secoverine selectively antagonizes muscarinic effects in various in vivo preparations.

J M Zwagemakers, V Claassen.   

Abstract

Time-activity studies of secoverine and atropine were made with respect to mydriasis and oxotremorine-induced salivation, lacrimation and tremors. Marked differences were found in the anticholinergic activity relation between secoverine and atropine for various tissues. These differences remained present at all time intervals, which excludes a pharmacokinetic explanation. It may be concluded that secoverine possesses a different affinity for various muscarinic receptors.

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Year:  1981        PMID： 7238585     DOI： 10.1016/0014-2999(81)90403-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

Review 1.  Rate-controlled drug dosage.

Authors:  J Urquhart
Journal:  Drugs       Date:  1982-03       Impact factor: 9.546

2.  Different muscarine receptors mediate the prejunctional inhibition of [3H]-noradrenaline release in rat or guinea-pig iris and the contraction of the rabbit iris sphincter muscle.

Authors:  H Fuder; J Schöpf; J Unckell; M T Wesner; C Melchiorre; R Tacke; E Mutschler; G Lambrecht
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-12       Impact factor: 3.000

3.  Enhancement by secoverine and physostigmine of retention of passive avoidance response in mice.

Authors:  A J Gower
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

4.  The effects of atropine and secoverine on gastric secretion and motility in the mouse isolated stomach.

Authors:  J S Davison; B Greenwood; A Najafi-Farashah; N W Read
Journal:  Br J Pharmacol       Date:  1983-06       Impact factor: 8.739

5.  The effect of secoverine hydrochloride on stimulated sigmoid motility: a double-blind, placebo controlled cross-over study in irritable bowel syndrome.

Authors:  M Ehsanullah; D A Lee; T Williams; P Pollard; B Gazzard
Journal:  Br J Clin Pharmacol       Date:  1985-03       Impact factor: 4.335

6.  Interaction of some muscarinic agonists and antagonists at the prejunctional muscarinic receptor in the rabbit ear artery preparation.

Authors:  L K Choo; F Mitchelson; Y M Vong
Journal:  Br J Pharmacol       Date:  1986-04       Impact factor: 8.739
  6 in total

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