| Literature DB >> 6652343 |
J S Davison, B Greenwood, A Najafi-Farashah, N W Read.
Abstract
The isolated perfused stomach of the mouse was used to study the effect of atropine and secoverine on bethanechol-induced gastric acid secretion and gastric motility. Both atropine and secoverine inhibited cholinergically induced gastric acid secretion and gastric motility. Inhibition of gastric acid secretion by atropine and secoverine occurred at a similar dose-range (10(-9) and 2 X 10(-9) M). Secoverine inhibited bethanechol-induced hypermotility at doses (10(-11) M and above) that were lower than those of atropine (2 X 10(-9) M and above) required to produce this effect. Secoverine, unlike atropine markedly inhibited gastric motility at lower doses than those which affected secretion.Entities:
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Year: 1983 PMID： 6652343 PMCID： PMC2044866 DOI： 10.1111/j.1476-5381.1983.tb11027.x
Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739