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Literature DB >> 7236986

A comparison of the effects of nifedipine and verapamil on rat vas deferens.

Abstract

Nifedipine preferentially blocks contractions of the prostatic end of the rat vas deferens to single pulse field stimulation, leaving the epididymal end largely unaffected. This action is not due entirely to antagonism of calcium influx. Verapamil unexpectedly potentiated the responses of the prostatic portion, and antagonized those of the epididymal end. The use of nifedipine may, therefore, allow investigations of adrenergic mechanisms on this tissue to be studied without the complications of non-adrenergic transmission.

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Year: 1981 PMID： 7236986 PMCID： PMC2071662 DOI： 10.1111/j.1476-5381.1981.tb10424.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

4 in total

Review 1. Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.

Authors: A Fleckenstein
Journal: Annu Rev Pharmacol Toxicol Date: 1977 Impact factor: 13.820

2. Verapamil blockade of slow Na+ and Ca++ responses in myocardial cells.

Authors: K Shigenobu; J A Schneider; N Sperelakis
Journal: J Pharmacol Exp Ther Date: 1974-08 Impact factor: 4.030

3. An analysis of the anatomical basis for the mechanical response to motor nerve stimulation of the rat vas deferens.

Authors: P G Anton; M E Duncan; J C McGrath
Journal: J Physiol Date: 1977-12 Impact factor: 5.182

4. Adrenergic and 'non-adrenergic' components in the contractile response of the vas deferens to a single indirect stimulus.

Authors: J C McGrath
Journal: J Physiol Date: 1978-10 Impact factor: 5.182

4 in total

19 in total

1. Bretylium or 6-OHDA-resistant, action potential-evoked Ca2+ transients in varicosities of the mouse vas deferens: commentary on Jackson and Cunnane.

Authors: J C McGrath
Journal: Br J Pharmacol Date: 2002-04 Impact factor: 8.739

2. Interactions of calcium antagonists and the calcium channel agonist Bay K 8644 on neurotransmission of the mouse isolated vas deferens.

Authors: G A Rae; J B Calixto
Journal: Br J Pharmacol Date: 1989-02 Impact factor: 8.739

3. Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts.

Authors:
Journal: Br J Pharmacol Date: 1989-10 Impact factor: 8.739

4. Differential effects of calcium channel blockers on the responses of the rat vas deferens to intramural nerve stimulation and exogenous drugs.

Authors: N I Amobi; I C Smith
Journal: Experientia Date: 1986-04-15

8. Effects of nifedipine and ryanodine on adrenergic neurogenic contractions of rat vas deferens: evidence for a pulse-to-pulse change in Ca2+ sources.

Authors: R Bültmann; I von Kügelgen; K Starke
Journal: Br J Pharmacol Date: 1993-04 Impact factor: 8.739

9. Effects of prostaglandin E2 on fast and slow components of the response of the rat vas deferens to field stimulation.

Authors: J R Bedwani; P E Blanning
Journal: Br J Pharmacol Date: 1983-01 Impact factor: 8.739

10. Post-natal development of functional neurotransmission in rat vas deferens.

Authors: A MacDonald; J C McGrath
Journal: Br J Pharmacol Date: 1984-05 Impact factor: 8.739