Literature DB >> 7236508

Serum and saliva levels of 8-methoxypsoralen after rectal administration as a micro-enema.

L Stolk, A H Siddiqui, A Kammeyer, R H Cormane, P A van Zwieten.   

Abstract

Serum and saliva concentrations of 8-methoxypsoralen (8-MOP) were determined in seven healthy human volunteers after rectal administration of a micro-enema. High peak serum levels were reached very soon(0.7 + or - 0.3 h) after administration of 8-MOP. Nausea was not experienced. There was a reasonable good linear correlation between 8-MOP concentrations in saliva and serum (r = 0.937). The saliva/serum ratio for 8-MOP concentration was 0.08 +/- 0.02.

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Year:  1981        PMID: 7236508     DOI: 10.1111/j.1365-2133.1981.tb15316.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN: 0007-0963            Impact factor:   9.302


  3 in total

1.  Comparison of serum levels and clinical results of PUVA therapy with three different dosage forms of 8-methoxypsoralen.

Authors:  A H Siddiqui; L M Stolk; R H Cormane
Journal:  Arch Dermatol Res       Date:  1984       Impact factor: 3.017

2.  Microenema of 8-methoxypsoralen in photochemotherapy of psoriasis.

Authors:  A H Siddiqui; L Stolk; H R Korthals Altes-Levij van Vinninghe; A Kammeijer; R H Cormane
Journal:  Arch Dermatol Res       Date:  1982       Impact factor: 3.017

Review 3.  Clinical pharmacokinetics of methoxsalen and other psoralens.

Authors:  F A de Wolff; T V Thomas
Journal:  Clin Pharmacokinet       Date:  1986 Jan-Feb       Impact factor: 6.447

  3 in total

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