Literature DB >> 7236322

DNA/anti-DNA complexes: correlation of size and complement fixation.

S J Waller, R P Taylor, E L Wright, K W Morley, M Johns.   

Abstract

The hydrodynamic sizes of antibody/3H-dsDNA immune complexes are correlated with their ability to fix complement in a red blood cell-complement linked binding assay. The results with PM2 dsDNA and a sonicated preparation (with a molecular weight of approximately 5.10(5) suggest that packing considerations are also important in the complement binding reaction. The relevance of these findings with respect to the role of antibody/dsDNA immune complexes in the pathogenesis of glomerulonephritis in systemic lupus erythematosus is discussed.

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Year:  1981        PMID： 7236322     DOI： 10.1002/art.1780240504

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  8 in total

1.  The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions.

Authors:  Y M Lucisano Valim; P J Lachmann
Journal:  Clin Exp Immunol       Date:  1991-04       Impact factor: 4.330

2.  Differential binding of immunoglobulin A and immunoglobulin G1 immune complexes to primate erythrocytes in vivo. Immunoglobulin A immune complexes bind less well to erythrocytes and are preferentially deposited in glomeruli.

Authors:  F J Waxman; L A Hebert; F G Cosio; W L Smead; M E VanAman; J M Taguiam; D J Birmingham
Journal:  J Clin Invest       Date:  1986-01       Impact factor: 14.808

3.  Quantitative analyses of complement fixation in three immune complex systems.

Authors:  C Horgan; R P Taylor
Journal:  Immunology       Date:  1984-08       Impact factor: 7.397

4.  Complement-component-C3-opsonized immunoglobulin G anti-DNA antibodies do not bind effectively to red blood cells unless aggregated on a high-Mr DNA matrix.

Authors:  C Horgan; R P Taylor
Journal:  Biochem J       Date:  1984-12-15       Impact factor: 3.857

5.  Primate erythrocyte-immune complex-clearing mechanism.

Authors:  J B Cornacoff; L A Hebert; W L Smead; M E VanAman; D J Birmingham; F J Waxman
Journal:  J Clin Invest       Date:  1983-02       Impact factor: 14.808

6.  Quantitative studies of the interaction of 3H-dsDNA/anti-DNA immune complexes with complement: comparison and evaluation of the Raji cell, the solution phase C1Q, and the red blood cell linked complement fixation radioimmunoassays.

Authors:  R P Taylor; B S Andrews; K W Morley; T Conlon
Journal:  Rheumatol Int       Date:  1981       Impact factor: 2.631

7.  Studies of artificial cryoprecipitates containing anti-DNA antibody activity.

Authors:  R P Taylor; S J Waller; J S Davis; J B Winfield; K W Morley; E L Wright
Journal:  Rheumatol Int       Date:  1981       Impact factor: 2.631

Review 8.  Anti-DNA antibodies--quintessential biomarkers of SLE.

Authors:  David S Pisetsky
Journal:  Nat Rev Rheumatol       Date:  2015-11-19       Impact factor: 20.543
  8 in total

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