Literature DB >> 6611301

Quantitative analyses of complement fixation in three immune complex systems.

C Horgan, R P Taylor.   

Abstract

The quantitative interaction of three different immune complex systems with complement has been investigated. dsDNA/anti-DNA, heat-aggregated IgG subfractions, and human IgG/rabbit anti-human IgG complexes were tested for their ability to consume complement (immune haemolysis assay) and to bind to red blood cells in a complement-mediated reaction (the RBC-CF assay). Our results indicate that some physical and immunological properties of the dsDNA/anti-DNA immune complex systems are significantly different from those of immune complexes that involve more common globular protein antigens. This difference in properties may help explain the role of dsDNA/anti-DNA immune complexes in systemic lupus erythematosus pathogenesis.

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Year:  1984        PMID： 6611301      PMCID： PMC1454649     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  16 in total

1.  Influence of molecular weight of DNA on the determination of anti-DNA antibodies in systemic lupus erythematosus (SLE) sera by radioimmunoassay.

Authors:  M Geisert; B Heicke; E Metzmann; R K Zahn
Journal:  Nucleic Acids Res       Date:  1975-04       Impact factor: 16.971

2.  Isolation of stable aggregates of IgG by zonal ultracentrifugation in sucrose gradients containing albumin.

Authors:  D W Knutson; A Kijlstra; H Lentz; L A van Es
Journal:  Immunol Commun       Date:  1979

Review 3.  Immunopathogenesis of systemic lupus erythematosus.

Authors:  D Koffler
Journal:  Annu Rev Med       Date:  1974       Impact factor: 13.739

Review 4.  Mechanism of solubilization of immune aggregates by complement. Implications for immunopathology.

Authors:  M Takahashi; J Czop; A Ferreira; V Nussenzweig
Journal:  Transplant Rev       Date:  1976

5.  The complement-mediated binding of soluble antibody/dsDNA immune complexes to human neutrophils.

Authors:  R P Taylor; J Burge; C Horgan; D M Shasby
Journal:  J Immunol       Date:  1983-06       Impact factor: 5.422

6.  DNA/anti-DNA complexes: correlation of size and complement fixation.

Authors:  S J Waller; R P Taylor; E L Wright; K W Morley; M Johns
Journal:  Arthritis Rheum       Date:  1981-05

7.  Stability of DNA/ANTI-DNA complexes. IV. Complement fixation.

Authors:  S E Pedersen; R P Taylor; K W Morley; E L Wright
Journal:  J Immunol Methods       Date:  1980       Impact factor: 2.303

8.  Detection of low avidity anti-DNA antibodies in systemic lupus erythematosus.

Authors:  R L Riley; H McGrath; R P Taylor
Journal:  Arthritis Rheum       Date:  1979-03

9.  Aggregated human immunoglobulin G stabilized by albumin: a standard for immune complex detection.

Authors:  R H Kauffmann; L A Van Es; M R Daha
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303

10.  A polyethylene glycol radioimmunoprecipitation assay for human immunoglobulin G.

Authors:  S J Waller; R P Taylor; B S Andrews
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303
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  1 in total

1.  Physical and biological studies on DNA/anti-DNA immune complex formed in vitro.

Authors:  Y Gao; P Wang; A Tajima; M Matsumura
Journal:  Cytotechnology       Date:  1997-11       Impact factor: 2.058
  1 in total

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