Literature DB >> 7228948

Determination of 1,4- and 1,5-benzodiazepines in urine using a computerized gas chromatographic-mass spectrometric technique.

H Maurer, K Pfleger.   

Abstract

A method for the determination of benzodiazepines and their main metabolites in urine after acid hydrolysis is described. The extract is analyzed by computerized gas chromatography-mass spectrometry. An on-line computer allows rapid detection using mass fragmentography with the masses m/e 211, 230, 241, 244, 249, 262, 276, and 285. The mass fragmentogram and the underlying mass spectra of the hydrolysis products (benzophenones and analogues) are documented.

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Year:  1981        PMID： 7228948     DOI： 10.1016/s0378-4347(00)84141-9

Source DB:  PubMed          Journal:  J Chromatogr


  5 in total

1.  Identification of phenothiazine antihistamines and their metabolites in urine.

Authors:  H Maurer; K Pfleger
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

Review 2.  Modern screening strategies in analytical toxicology with special regard to new benzodiazepines.

Authors:  H Schütz
Journal:  Z Rechtsmed       Date:  1988

3.  A rapid solid-phase extraction and HPLC/DAD procedure for the simultaneous determination and quantification of different benzodiazepines in serum, blood and post-mortem blood.

Authors:  F Musshoff; T Daldrup
Journal:  Int J Legal Med       Date:  1992       Impact factor: 2.686

4.  Positive and negative ion mass spectrometry of benzophenones, the acid-hydrolysis products of benzodiazepines.

Authors:  O Suzuki; H Hattori; M Asano; T Takahashi; H Brandenberger
Journal:  Z Rechtsmed       Date:  1987

5.  A specific immunoassay for the detection of flunitrazepam.

Authors:  A West; H Köhler-Schmidt; S Baudner; G Blaschke
Journal:  Int J Legal Med       Date:  1995       Impact factor: 2.686
  5 in total

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