Literature DB >> 7228947

Simultaneous measurement of dothiepin and its major metabolites in plasma and whole blood by gas chromatography-mass fragmentography.

K P Maguire, T R Norman, G D Burrows, B A Scoggins.   

Abstract

A method for the simultaneous measurement of dothiepin and two of its major metabolites, northiaden and dothiepin S-oxide in both plasma and whole blood is described. The method involves the use of gas chromatography-mass fragmentography. It is selective, sensitive (1 microgram/1) and reproducible. It has been used to analyse both plasma and blood samples following single oral doses of 75 mg dothiepin in seven volunteers.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7228947     DOI： 10.1016/s0378-4347(00)84140-7

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

1.  A pharmacokinetic study of mianserin.

Authors:  K P Maguire; T R Norman; G D Burrows; B A Scoggins
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

2.  Clinical pharmacokinetics of dothiepin. Single-dose kinetics in patients and prediction of steady-state concentrations.

Authors:  K P Maguire; T R Norman; I McIntyre; G D Burrows
Journal:  Clin Pharmacokinet       Date:  1983 Mar-Apr       Impact factor: 6.447

3.  Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline.

Authors:  C Ogura; A Kishimoto; R Mizukawa; H Hazama; H Honma; K Kawahara
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

4.  Metabolism and pharmacokinetics of dothiepin.

Authors:  K P Maguire; G D Burrows; T R Norman; B A Scoggins
Journal:  Br J Clin Pharmacol       Date:  1981-09       Impact factor: 4.335
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.