| Literature DB >> 7075657 |
K P Maguire, T R Norman, G D Burrows, B A Scoggins.
Abstract
The kinetics of mianserin have been evaluated in eight healthy male volunteers following a single oral dose of 60 mg. Plasma and blood concentrations of mianserin were measured by gas chromatography-mass fragmentography. The peak blood concentration observed was 65 microgram/1 at 3 h following the dose. Mean kinetic parameters (and range) calculated from the blood concentrations were: (t1/2)abs 1.1 h (0.3-2.8), (t1/2) alpha 2.5 h (0.9-4.7), (t1/2) beta 21 h (14-33), (Vd) beta 27.5 l/kg (16.8-46.5) and Cloral 0.98 l/kg/h (0.47-1.75). Blood/plasma concentration ratios ranged from 0.50-0.74.Entities:
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Year: 1982 PMID： 7075657 DOI： 10.1007/bf00542048
Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953