Literature DB >> 7228502

Peptide segment coupling in aqueous medium: silver ion activation of the thiolcarboxyl group.

J Blake.   

Abstract

The use of the thiolcarboxyl function for the assemblage of deblocked peptide segments in aqueous medium has been investigated. The C-terminal thiolcarboxyl peptide Ac-Tyr-Arg-Arg-Glu-Arg-Gly-SH (2a) has been synthesized by the solid-phase method. The silver compound of peptide 2a was coupled to H-Phe-Ala-Glu-Gly-OH in 50% aqueous dimethylformamide to give a 40% yield of Ac-Tyr-Arg-Arg-Glu-Arg-Gly-Phe-Ala-Glu-Gly-OH.

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Year:  1981        PMID: 7228502     DOI: 10.1111/j.1399-3011.1981.tb01992.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN: 0367-8377


  14 in total

1.  Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology.

Authors:  T M Hackeng; J H Griffin; P E Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

2.  Native chemical ligation at valine: a contribution to peptide and glycopeptide synthesis.

Authors:  Jin Chen; Qian Wan; Yu Yuan; Jianglong Zhu; Samuel J Danishefsky
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

Review 3.  Toward fully synthetic, homogeneous glycoproteins: advances in chemical ligation.

Authors:  Yu Yuan; Jin Chen; Qian Wan; Rebecca M Wilson; Samuel J Danishefsky
Journal:  Biopolymers       Date:  2010       Impact factor: 2.505

4.  Total synthesis of human beta-lipotropin.

Authors:  J Blake; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

5.  Dihydro-3-(triphenylphosphoranylidene)-2,5-thiophendione: A Convenient Synthon for the Preparation of Substituted 1,4-Thiazepin-5-ones and Piperidinones via the Intermediacy of Thioacids.

Authors:  David Crich; Md Yeajur Rahaman
Journal:  Tetrahedron       Date:  2010-08-14       Impact factor: 2.457

6.  Preparation of fully synthetic histone H3 reveals that acetyl-lysine 56 facilitates protein binding within nucleosomes.

Authors:  John C Shimko; Justin A North; Aaron N Bruns; Michael G Poirier; Jennifer J Ottesen
Journal:  J Mol Biol       Date:  2011-02-15       Impact factor: 5.469

Review 7.  Rethinking amide bond synthesis.

Authors:  Vijaya R Pattabiraman; Jeffrey W Bode
Journal:  Nature       Date:  2011-12-21       Impact factor: 49.962

8.  Reaction of thioacids with isocyanates and isothiocyanates: a convenient amide ligation process.

Authors:  David Crich; Kaname Sasaki
Journal:  Org Lett       Date:  2009-08-06       Impact factor: 6.005

Review 9.  The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last.

Authors:  Rebecca M Wilson; Suwei Dong; Ping Wang; Samuel J Danishefsky
Journal:  Angew Chem Int Ed Engl       Date:  2013-06-17       Impact factor: 15.336

10.  New segment-coupling method for peptide synthesis in aqueous solution: application to synthesis of human [Gly17]-beta-endorphin.

Authors:  J Blake; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

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