Literature DB >> 722755

Antiviral activity of some beta-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses.

G D Diana, P M Carabateas, R E Johnson, G L Williams, F Pancic, J C Collins.   

Abstract

The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both RNA and DNA viruses. Compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time.

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Year:  1978        PMID： 722755     DOI： 10.1021/jm00207a010

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  7 in total

Review 1.  Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.

Authors:  Anna Egorova; Sean Ekins; Michaela Schmidtke; Vadim Makarov
Journal:  Eur J Med Chem       Date:  2019-06-11       Impact factor: 6.514

Review 2.  Emergent mechanistic diversity of enzyme-catalysed beta-diketone cleavage.

Authors:  Gideon Grogan
Journal:  Biochem J       Date:  2005-06-15       Impact factor: 3.857

3.  Antirhinovirus activity of purine nucleoside analogs.

Authors:  E De Clercq; R Bernaerts; D E Bergstrom; M J Robins; J A Montgomery; A Holy
Journal:  Antimicrob Agents Chemother       Date:  1986-03       Impact factor: 5.191

4.  Biological Investigations of Ru(II) Complexes With Diverse β-diketone Ligands.

Authors:  Raphael T Ryan; Dmytro Havrylyuk; Kimberly C Stevens; L Henry Moore; Sean Parkin; Jessica S Blackburn; David K Heidary; John P Selegue; Edith C Glazer
Journal:  Eur J Inorg Chem       Date:  2021-07-21       Impact factor: 2.551

5.  Antiviral activity of Win 41258-3, a pyrazole compound, against herpes simplex virus in mouse genital infection and in guinea pig skin infection.

Authors:  F Pancic; B A Steinberg; G D Diana; P M Carabateas; W G Gorman; P E Came
Journal:  Antimicrob Agents Chemother       Date:  1981-03       Impact factor: 5.191

6.  Crystal structure of (Z)-3-[5-chloro-2-(prop-2-yn-yloxy)phen-yl]-3-hy-droxy-1-[4-(tri-fluoro-meth-yl)phen-yl]-prop-2-en-1-one.

Authors:  Aarti Dalal; Ramesh C Kamboj; Dinesh Kumar; Mahendra Kumar Sharma; Nagendran Selvarajan
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-07-08

Review 7.  Targeting the Virus Capsid as a Tool to Fight RNA Viruses.

Authors:  Lucie Hozáková; Barbora Vokatá; Tomáš Ruml; Pavel Ulbrich
Journal:  Viruses       Date:  2022-01-18       Impact factor: 5.048
  7 in total

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