Literature DB >> 722734

4-(6-Methoxy-2-naphthyl)butan-2-one and related analogues, a novel structural class of antiinflammatory compounds.

A C Goudie, L M Gaster, A W Lake, C J Rose, P C Freeman, B O Hughes, D Miller.   

Abstract

A series of compounds related to 4-(6-methoxy-2-naphthyl)butan-2-one has been prepared and tested for antiinflammatory activity by the cotton pellet granuloma method. Compounds possessing a small lipophilic group such as methoxyl, methyl, or chloro in the 6 position in conjunction with a butan-2-one side chain in the 2 position of the naphthalene ring were most active. The indtroduction of a methyl group along the side chain was invariably deleterious. Good activity was generally retained by forming esters of a butan-2-ol side chain.

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Year:  1978        PMID： 722734     DOI： 10.1021/jm00210a016

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  7 in total

1.  Analgesic activity of nabumetone in postoperative pain.

Authors:  P Movilia; L Restelli; F Miriano; G Vaiani; E Grossi
Journal:  Drugs       Date:  1990       Impact factor: 9.546

2.  A pharmacokinetic study of the active metabolite of nabumetone in young healthy subjects and older arthritis patients.

Authors:  M J Kendall; M C Chellingsworth; R Jubb; A R Thawley; N A Undre; D C Kill
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

3.  Novel and convenient synthesis of 1-(pyridinylmethyl)-2-naphthols and 1-(pyridinylmethylene)-2-tetralones from 2-tetralones.

Authors:  Po-Jung J Huang; Elizabeth Potter; Amitabh Jha
Journal:  Mol Divers       Date:  2009-08-07       Impact factor: 2.943

Review 4.  Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxygenase-2 inhibition?

Authors:  N M Davies
Journal:  Clin Pharmacokinet       Date:  1997-12       Impact factor: 6.447

5.  Carbon-carbon bond cleavage in activation of the prodrug nabumetone.

Authors:  Fatbardha Varfaj; Siti N A Zulkifli; Hyoung-Goo Park; Victoria L Challinor; James J De Voss; Paul R Ortiz de Montellano
Journal:  Drug Metab Dispos       Date:  2014-02-28       Impact factor: 3.922

Review 6.  Nabumetone. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases.

Authors:  H A Friedel; P A Todd
Journal:  Drugs       Date:  1988-05       Impact factor: 9.546

7.  Crystal structures of three 1-oxo-1,2-di-hydro-naphthalene derivatives: dimethyl 4-(4-meth-oxy-phen-yl)-2-(4-methyl-phen-yl)-1-oxo-1,2-di-hydro-naphthalene-2,3-di-carboxyl-ate, dimethyl 1-oxo-2-(pyren-4-yl)-4-(thio-phen-2-yl)-1,2-di-hydro-naphthalene-2,3-di-carboxyl-ate and ethyl 1-oxo-2-phenyl-2,4-bis-(thio-phen-2-yl)-1,2-di-hydro-naphthalene-3-carboxyl-ate.

Authors:  S Gopinath; P Narayanan; K Sethusankar; Jeyachandran Karunakaran; Meganathan Nandakumar; Arasambattu K Mohanakrishnan
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-01-13
  7 in total

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