Literature DB >> 7211844

Segregation analysis of congenital glaucoma: approach by two differential models.

F Demenais, R C Elston, C Bonaiti, M L Briard, E B Kaplan, K K Namboodiri.   

Abstract

To determine the mode of inheritance of congenital glaucoma, segregation analysis was performed using two different models: the transmission probability model and the mixed model. Whereas the latter, testing for monogenic inheritance in the presence of both monogenic and polygenic components, results in strong evidence for a major locus, the former, testing for Mendelian segregation at one locus, rejects this hypothesis. The differences in the results of these two models are discussed and are attributed to the underlying structure of each. Genetic heterogeneity of congenital glucoma is proposed.

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Year:  1981        PMID： 7211844      PMCID： PMC1684943     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  7 in total

1.  [The genetics of congenital glaucoma: a study of 231 cases].

Authors:  M L Briard; J Feingold; J Kaplan; C Bonaiti; J J Aron; M F Blanck; S Delthil; J Frezal
Journal:  J Genet Hum       Date:  1976-11

2.  Sampling considerations in the gathering and analysis of pedigree data.

Authors:  R C Elston; E Sobel
Journal:  Am J Hum Genet       Date:  1979-01       Impact factor: 11.025

3.  Analysis of family resemblance. 3. Complex segregation of quantitative traits.

Authors:  N E Morton; C J MacLean
Journal:  Am J Hum Genet       Date:  1974-07       Impact factor: 11.025

4.  Complex segregation analysis.

Authors:  N E Morton; S Yee; R Lew
Journal:  Am J Hum Genet       Date:  1971-11       Impact factor: 11.025

5.  A general model for the genetic analysis of pedigree data.

Authors:  R C Elston; J Stewart
Journal:  Hum Hered       Date:  1971       Impact factor: 0.444

6.  Major locus analysis for quantitative traits.

Authors:  R C Elston
Journal:  Am J Hum Genet       Date:  1979-11       Impact factor: 11.025

7.  Congenital glaucoma: genetic models.

Authors:  F Demenais; C Bonaïti; M L Briard; J Feingold; J Frézal
Journal:  Hum Genet       Date:  1979-02-15       Impact factor: 4.132
  7 in total
  6 in total

1.  A unified model for complex segregation analysis.

Authors:  J M Lalouel; D C Rao; N E Morton; R C Elston
Journal:  Am J Hum Genet       Date:  1983-09       Impact factor: 11.025

2.  Further analysis of familial transmission of congenital glaucoma.

Authors:  F Demenais
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

3.  On the possibility of pleiotropic monogenic control of hereditary polyposis and primary cancer of the colon.

Authors:  E K Ginsburg; T I Axenovich; B A Altshouler; M D Bazhenova
Journal:  Am J Hum Genet       Date:  1989-02       Impact factor: 11.025

4.  Congenital glaucoma due to dominant goniodysgenesis. A new concept of the heredity of glaucoma.

Authors:  T Jerndal
Journal:  Am J Hum Genet       Date:  1983-07       Impact factor: 11.025

5.  Population genetical aspects of primary congenital glaucoma. I. Incidence, prevalence, gene frequency, and age of onset.

Authors:  A Gencik; A Gencikova; V Ferák
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

6.  Exome sequencing identifies procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 mutations in primary congenital and juvenile glaucoma.

Authors:  Viney Gupta; Bindu I Somarajan; Gagandeep Kaur; Shikha Gupta; Renu Singh; Dibyabhaba Pradhan; Harpreet Singh; Punit Kaur; Anshul Sharma; Bindia Chawla; Anisha Pahuja; Rajesh Ramachandran; Arundhati Sharma
Journal:  Indian J Ophthalmol       Date:  2021-10       Impact factor: 1.848
  6 in total

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