Literature DB >> 7208355

Transcriptional errors and ambiguity resulting from the presence of 1,N6-ethenoadenosine or 3,N4-ethenocytidine in polyribonucleotides.

S Spengler, B Singer.   

Abstract

1,N6-Ethenoadenosine (epsilon A) and 3,N4-Ethenocytidine (epsilon C) in copolymers with unmodified nucleosides were transcribed using DNA-dependent RNA polymerase in the presence of Mn2+. Nearest neighbor analysis of the products showed that epsilon A directed incorporation of A much greater than U greater than C while epsilon C directed the incorporation of U greater than or equal to A much greater than C Neither directed G into the complementary polymer. Such misincorporations resulting from epsilon A and epsilon C, compounds that are formed in vivo by the carcinogen vinyl chloride, may have a biological role as promutagens.

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Year:  1981        PMID： 7208355      PMCID： PMC326698          DOI： 10.1093/nar/9.2.365

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  22 in total

1.  Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride.

Authors:  A Barbin; H Brésil; A Croisy; P Jacquignon; C Malaveille; R Montesano; H Bartsch
Journal:  Biochem Biophys Res Commun       Date:  1975-11-17       Impact factor: 3.575

2.  Crystal and molecular structure of 3,N4-ethenocytidine hydrochloride. A study of the dimensions and molecular interactions of the fluorescent epsilon-cytidine system.

Authors:  A H Wang; J R Barrio; I C Paul
Journal:  J Am Chem Soc       Date:  1976-11-10       Impact factor: 15.419

3.  Synthesis and properties of a new fluorescent polynucleotide, poly(1,N6-ethenoadenylic acid).

Authors:  H Lehrach; K H Scheit
Journal:  Biochim Biophys Acta       Date:  1973-04-21

4.  Fluorescent adenosine and cytidine derivatives.

Authors:  J R Barrio; J A Secrist; N J Leonard
Journal:  Biochem Biophys Res Commun       Date:  1972-01-31       Impact factor: 3.575

5.  Synthesis and properties of poly (1,N-6-ethenoadenylic acid) and poly (3,N-4-ethenocytidylic acid).

Authors:  B Janik; R G Sommer; M P Kotick; D P Wilson; J Erickson
Journal:  Physiol Chem Phys       Date:  1973

6.  Chloroacetaldehyde-modified dinucleoside phosphates. Dynamic fluorescence quenching and quenching due to intramolecular complexation.

Authors:  G L Tolman; J R Barrio; N J Leonard
Journal:  Biochemistry       Date:  1974-11-19       Impact factor: 3.162

7.  Messenger and template activities of chemically modified polynucleotides.

Authors:  B Singer; H Fraenkel-Conrat
Journal:  Biochemistry       Date:  1970-09-15       Impact factor: 3.162

Review 8.  Mutagenic and carcinogenic effects of vinyl chloride.

Authors:  H Bartsch; R Montesano
Journal:  Mutat Res       Date:  1975       Impact factor: 2.433

9.  The crystal and molecular structure of a derivative of 1,N6-ethenoadenosine hydrochloride. Dimensions and molecular interactions of the fluorescent epsilon-adenosine (epsilon-ado) system.

Authors:  A H Wang; L G Dammann; J R Barrio; I C Paul
Journal:  J Am Chem Soc       Date:  1974-02-20       Impact factor: 15.419

10.  Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide.

Authors:  J McCann; V Simmon; D Streitwieser; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205
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  8 in total

Review 1.  DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans.

Authors:  Byeong Hwa Yun; Jingshu Guo; Medjda Bellamri; Robert J Turesky
Journal:  Mass Spectrom Rev       Date:  2018-06-11       Impact factor: 10.946

2.  Cloning and molecular characterization of csm mutations allowing expression of catabolite-repressible operons in the absence of exogenous cyclic AMP.

Authors:  S E George; T Melton
Journal:  J Bacteriol       Date:  1986-05       Impact factor: 3.490

3.  Escherichia coli, Saccharomyces cerevisiae, rat and human 3-methyladenine DNA glycosylases repair 1,N6-ethenoadenine when present in DNA.

Authors:  M Saparbaev; K Kleibl; J Laval
Journal:  Nucleic Acids Res       Date:  1995-09-25       Impact factor: 16.971

4.  In vitro discrimination of replicases acting on carcinogen-modified polynucleotide templates.

Authors:  B Singer; J T Kuśmierek; H Fraenkel-Conrat
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

5.  A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch.

Authors:  B Hang; M Medina; H Fraenkel-Conrat; B Singer
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

6.  Impact of 1,N 6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair.

Authors:  Pratibha P Ghodke; F Peter Guengerich
Journal:  J Biol Chem       Date:  2020-03-25       Impact factor: 5.157

7.  Mechanisms of mutagenesis by chloroacetaldehyde.

Authors:  J S Jacobsen; C P Perkins; J T Callahan; K Sambamurti; M Z Humayun
Journal:  Genetics       Date:  1989-02       Impact factor: 4.562

8.  Mechanisms of vinyl chloride carcinogenicity/mutagenicity.

Authors:  D E Hathaway
Journal:  Br J Cancer       Date:  1981-10       Impact factor: 7.640
  8 in total

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