Literature DB >> 7207638

Protective effect of anionic cholecystographic agents against phalloidin on isolated hepatocytes by competitive inhibition of the phallotoxin uptake. Comparison of the influence on the inward transport of 3H-demethylphalloin and of 14C-cholate.

M Frimmer, E Petzinger, K Ziegler.   

Abstract

Several anionic substances used for cholecystography inhibit the development of protrusions in isolated hepatocytes in response to phalloidin. Drugs from the iopodate family were equieffective with those of th iodipamide type. The above protective effect results from a competitive inhibition of the phallotoxin uptake as shown for iopodate. Cholecystographic agents similarly inhibit the inward transport of cholic acid in a competitive manner. The inhibition of the phallotoxin response is inversely correlated with the uptake of 3H-demethylphalloin (r = 0.94) and with the inward transport of cholate (r = 0.84) at various inhibiting concentrations of iopodate.

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Year:  1980        PMID： 7207638     DOI： 10.1007/bf00505808

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  8 in total

1.  The significance of protein binding of contrast media in roentgen diagnosis.

Authors:  E C LASSER; R S FARR; T FUJIMAGARI; W N TRIPP
Journal:  Am J Roentgenol Radium Ther Nucl Med       Date:  1962-02

2.  Decreased sensitivity of isolated hepatocytes from baby rats, from regenerating and from poisoned livers to phalloidin.

Authors:  K Ziegler; E Petzinger; E Grundmann; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-04       Impact factor: 3.000

3.  The role of bile acids in phalloidin poisoning.

Authors:  M Frimmer; E Petzinger; U Rufeger; L B Veil
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-12       Impact factor: 3.000

4.  Binding of roentgenographic contrast media to serum albumin.

Authors:  J H Lang; E C Lasser
Journal:  Invest Radiol       Date:  1967 Nov-Dec       Impact factor: 6.016

5.  [Phalloidin antagonists 4th communication: Thioctic acid, SH-compounds, rifampicin, choleretics, dexamethasone, estradiol, unspecific inhibitors, and ineffective compounds (author's transl)].

Authors:  M Frimmer; E Petzinger; J Homann
Journal:  Arzneimittelforschung       Date:  1975

6.  Uptake of 3H-demethylphalloin by isolated hepatocytes in the presence of various concentrations of phalloin or phalloidin.

Authors:  M Frimmer; E Petzinger; K Ziegler; L B Veil
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-02       Impact factor: 3.000

7.  Comparative studies on the uptake of 14C-bile acids and 3H-demethylphalloin in isolated rat liver cells.

Authors:  E Petzinger; M Frimmer
Journal:  Arch Toxicol       Date:  1980-03       Impact factor: 5.153

8.  Inhibition of 3H-demethylphalloin uptake in isolated rat hepatocytes under various experimental conditions.

Authors:  E Petzinger; K Ziegler; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-07       Impact factor: 3.000
  8 in total
  10 in total

1.  Properties of phallotoxin uptake by basolateral plasma membrane vesicles from rat liver: evidence for a carrier-mediated transport.

Authors:  M Täfler; K Ziegler; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-02       Impact factor: 3.000

Review 2.  Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations.

Authors:  D K Meijer; W E Mol; M Müller; G Kurz
Journal:  J Pharmacokinet Biopharm       Date:  1990-02

3.  Affinity labels for membrane components involved in the uptake of bile acids and of phallotoxins by hepatocytes. Development of covalently binding derivatives of bile acids and of compounds related to cholecystographic agents.

Authors:  K Ziegler; M Frimmer; W Möller; H Fasold
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-06       Impact factor: 3.000

4.  Competitive inhibition of the uptake of demethylphalloin by cholic acid in isolated hepatocytes. Evidence for a transport competition rather than a binding competition.

Authors:  E Petzinger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-07       Impact factor: 3.000

5.  Chemical modification of membrane proteins by brominated taurodehydrocholate in isolated hepatocytes; relationship to the uptake of cholate and of phalloidin and to the sensitivity of hepatocytes to phalloidin.

Authors:  K Ziegler; M Frimmer; W Möller; H Fasold
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-06       Impact factor: 3.000

6.  Common properties of hepatocellular uptake of cholate, iodipamide and antamanide, as distinct from the uptake of bromosulfophthalein.

Authors:  E Petzinger; C Joppen; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-03       Impact factor: 3.000

7.  Properties of iodipamide uptake by isolated rat hepatocytes.

Authors:  C Joppen; E Petzinger; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-12       Impact factor: 3.000

8.  Identity of hepatic membrane transport systems for bile salts, phalloidin, and antamanide by photoaffinity labeling.

Authors:  T Wieland; M Nassal; W Kramer; G Fricker; U Bickel; G Kurz
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

9.  Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins.

Authors:  Thomas Fehrenbach; Yunhai Cui; Heinz Faulstich; Dietrich Keppler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-10-03       Impact factor: 3.000

10.  Lack of intestinal transport of [3H]-demethylphalloin: comparative studies with phallotoxins and bile acids on isolated small intestinal cells and ileal brush border membrane vesicles.

Authors:  E Petzinger; G Burckhardt; M Schwenk; H Faulstich
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-08       Impact factor: 3.000
  10 in total

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