Literature DB >> 720488

Inhibition of rat hepatic dimethylnitrosamine demethylase by cyclic and acyclic nitrosamines and secondary amines.

I Y Chau, M C Archer.   

Abstract

Inhibition of hepatic dimethylnitrosamine (DMN) metabolism by a variety of cyclic and acyclic nitrosamines was demonstrated. Nitrosoproline, a noncarcinogenic nitrosamine, behaved differently from the carcinogenic nitrosamines as an inhibitor for DMN-demethylase. Secondary amines corresponding to the nitrosamines inhibited DMN-demethylase in a manner similar to the nitrosamines.

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Year:  1978        PMID： 720488     DOI： 10.1007/bf01932378

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Comparative studies on hepatic dimethylnitrosamine demethylase and some xenobiotic-metabolizing enzymes in the rat.

Authors:  B G Lake; M J Minski; J C Phillips; C E Heading; S D Gangolli; A G Lloyd
Journal:  Biochem Soc Trans       Date:  1975       Impact factor: 5.407

2.  Suppression of hepatic DMN demethylase activity by nitrososarcosine and other nitrosamines.

Authors:  M A Friedman; D B Couch
Journal:  Biochem Pharmacol       Date:  1976-12-15       Impact factor: 5.858

3.  Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine.

Authors:  D Dagani; M C Archer
Journal:  J Natl Cancer Inst       Date:  1976-10       Impact factor: 13.506

4.  A sensitive colorimeter method for formaldehyde.

Authors:  J Chrastil; J T Wilson
Journal:  Anal Biochem       Date:  1975-01       Impact factor: 3.365

5.  Preliminary studies of the metabolism of N-nitroso[2,5-14Clpyrrolidine in the rat [proceedings].

Authors:  R C Cottrell; P J Young; I A Herod; B G Lake; J C Phillips; S D Gangolli
Journal:  Biochem Soc Trans       Date:  1977       Impact factor: 5.407
  5 in total

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