Literature DB >> 1003536

Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine.

D Dagani, M C Archer.   

Abstract

The rates of N-demethylation of dimethylnitrosamine and dimethylnitrosamine-d6 by rat liver microsomes were studied by monitoring formaldehyde production. Deuterium isotope effects of 1.6 and 3.8 were found for the Michaelis constant and the maximum velocity, respectively.

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Year:  1976        PMID： 1003536     DOI： 10.1093/jnci/57.4.955

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  4 in total

1.  Inhibition of rat hepatic dimethylnitrosamine demethylase by cyclic and acyclic nitrosamines and secondary amines.

Authors:  I Y Chau; M C Archer
Journal:  Experientia       Date:  1978-11-15

Review 2.  Deuterium isotope effects in carcinogenesis by N-nitroso compounds.

Authors:  W Lijinsky
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

3.  Structure/activity investigations in eight arylalkyltriazenes comparison of chemical stability, mode of decomposition, and SCE induction in Chinese hamster V79-E cells.

Authors:  R Thust; M Schneider; U Wagner; D Schreiber
Journal:  Cell Biol Toxicol       Date:  1991-04       Impact factor: 6.691

4.  Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine.

Authors:  A E Pegg; G Hui
Journal:  Biochem J       Date:  1978-09-01       Impact factor: 3.857
  4 in total

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