Literature DB >> 720478

Interaction of vinblastine analogues with tubulin.

F Zavala, D Guénard, P Potier.   

Abstract

Studies of the interaction between vinblastine-like alkaloids and their receptor, i.e. tubulin, are reported. They shed some light on the structure-activity relationships in this medicinally important series: the configurations at C14' and C16' as well as the presence of the methoxycarbonyl group on C16' seem to play an essential role in the determination of biological activity.

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Year:  1978        PMID： 720478     DOI： 10.1007/bf01932374

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Correlation of biologic data with physico-chemical properties among the vinca alkaloids and their congeners.

Authors:  R J Owellen; D W Donigian; C A Hartke; F O Hains
Journal:  Biochem Pharmacol       Date:  1977-07-01       Impact factor: 5.858

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Vinblastine and microtubules. II. Characterization of two protein subunits from the isolated crystals.

Authors:  J Bryan
Journal:  J Mol Biol       Date:  1972-04-28       Impact factor: 5.469

4.  Microtubule assembly in the absence of added nucleotides.

Authors:  M L Shelanski; F Gaskin; C R Cantor
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

5.  Characterization of microtubule assembly in porcine brain extracts by viscometry.

Authors:  J B Olmsted; G G Borisy
Journal:  Biochemistry       Date:  1973-10-09       Impact factor: 3.162

6.  Interaction of drugs with microtubule proteins.

Authors:  L Wilson; J R Bamburg; S B Mizel; L M Grisham; K M Creswell
Journal:  Fed Proc       Date:  1974-02

Review 7.  Biochemistry and physiology of microtubules.

Authors:  J A Snyder; J R McIntosh
Journal:  Annu Rev Biochem       Date:  1976       Impact factor: 23.643

8.  Investigation of the metabolic fate of tritiated vincristine in the rat by high-pressure liquid chromatography.

Authors:  M C Castle; J A Mead
Journal:  Biochem Pharmacol       Date:  1978-01-01       Impact factor: 5.858

9.  Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on microtubules in vitro.

Authors:  R H Himes; R N Kersey; I Heller-Bettinger; F E Samson
Journal:  Cancer Res       Date:  1976-10       Impact factor: 12.701

10.  Microtubule-macrotubule transitions: intermediates after exposure to the mitotic inhibitor vinblastine.

Authors:  R K Warfield; G B Bouck
Journal:  Science       Date:  1974-12-27       Impact factor: 47.728
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  1 in total

1.  Differential in vitro action of S-12363, a new vinblastine derivative, and of its epimer on microtubule proteins.

Authors:  M Wright; M Garès; P Verdier-Pinard; A Moisand; M Berlion; J J Legrand; J P Bizzari
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333
  1 in total

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