| Literature DB >> 4432069 |
Abstract
Vinblastine treatment of microtubule protein or intact microtubules assembled in vitro produced bifilar rings and bifilar helices. Suspentsions of rings and helices were demonstrated to bind [(3)H]colchicine, a diagnostic property of microtubule protein. Macrotubules are suggested to consist of tightly coiled helices formed by longitudinal compacting of loosely coiled protofilament pair intermediates.Entities:
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Year: 1974 PMID: 4432069 DOI: 10.1126/science.186.4170.1219
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728