Literature DB >> 7203530

No impairment of local intestinal immune response to keyhole limpet haemocyanin in the absence of Peyer's patches.

S R Hamilton, D F Keren, J H Yardley, G Brown.   

Abstract

The role of Peyer's patches in the local intestinal and serum antibody responses to keyhole limpet haemocyanin (KLH) was studied in rabbits with chronically isolated ileal loops. Four weekly doses of 400 microgram KLH were administered into loops prepared with and without Peyer's patches. Isotype-specific IgA and IgG anti-KLH in loop secretions collected twice each week and in sera collected weekly were assessed by enzyme-linked immunosorbent assay. Fluid IgA anti-KLH in loops without Peyer's patches first showed a statistically significant increase on day 25, 1 week later than control loops with Peyer's patches. However, some animals in the group without Peyer's patches showed a rise as early as day 7, and the differences from controls were not statistically significant at any time. No statistically significant rise in fluid or serum IgG anti-KLH occurred in either group. Thus, Peyer's patches were not essential for local intestinal antibody response to KLH, a soluble macromolecular antigen. The findings suggest that the innumerable small lymphoid nodules in the gastrointestinal tract, or other mechanisms of antigen processing, play an important role in local intestinal immune responses.

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Year:  1981        PMID: 7203530      PMCID: PMC1458454     

Source DB:  PubMed          Journal:  Immunology        ISSN: 0019-2805            Impact factor:   7.397


  9 in total

1.  Statistical evaluation of method-comparison data.

Authors:  G T Wu; S L Twomey; R E Thiers
Journal:  Clin Chem       Date:  1975-03       Impact factor: 8.327

2.  Proceedings: Antigen binding cells in rabbit Peyer's patches after intestinal immunisation.

Authors:  M H Wansbrough-Jones; M B Pepys; W F Doe
Journal:  Gut       Date:  1976-05       Impact factor: 23.059

3.  The role of Peyer's patches in the local immune response of rabbit ileum to live bacteria.

Authors:  D F Keren; P S Holt; H H Collins; P Gemski; S B Formal
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

4.  Enzyme-linked immunosorbent assay for immunoglobulin G and immunoglobulin A antibodies to Shigella flexneri antigens.

Authors:  D F Keren
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

5.  Suppression of local intestinal immunoglobulin A immune response to cholera toxin by subcutaneous administration of cholera toxoids.

Authors:  S R Hamilton; J H Yardley; G D Brown
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

6.  Local (immunoglobulin A) immune response by the intestine to cholera toxin and its partial suppression with combined systemic and intra-intestinal immunization.

Authors:  J H Yardley; D F Keren; S R Hamilton; G D Brown
Journal:  Infect Immun       Date:  1978-02       Impact factor: 3.441

7.  Origin and differentiation of lymphocytes involved in the secretory IgA responses.

Authors:  J J Cebra; P J Gearhart; R Kamat; S M Robertson; J Tseng
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

8.  Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: an ultrastructural study.

Authors:  R L Owen
Journal:  Gastroenterology       Date:  1977-03       Impact factor: 22.682

9.  The origin and antigen-dependent distribution of IgA-containing cells in the intestine.

Authors:  A J Husband; J L Gowans
Journal:  J Exp Med       Date:  1978-11-01       Impact factor: 14.307

  9 in total
  8 in total

1.  Immunoglobulin A cell distribution in the human small intestine: phenotypic and functional characteristics.

Authors:  I N Farstad; H Carlsen; H C Morton; P Brandtzaeg
Journal:  Immunology       Date:  2000-11       Impact factor: 7.397

2.  Immunoglobulin- and J chain-producing cells associated with lymphoid follicles in the human appendix, colon and ileum, including Peyer's patches.

Authors:  K Bjerke; P Brandtzaeg
Journal:  Clin Exp Immunol       Date:  1986-05       Impact factor: 4.330

3.  Induction of oral tolerance in rats without Peyer's patches.

Authors:  G Enders; T Gottwald; W Brendel
Journal:  Immunology       Date:  1986-06       Impact factor: 7.397

4.  The influence of Peyer's patches on the organ-specific distribution of IgA plasma cells.

Authors:  G A Enders; S Ballhaus; W Brendel
Journal:  Immunology       Date:  1988-03       Impact factor: 7.397

5.  In vitro immunoglobulin synthesis by human intestinal lamina propria lymphocytes.

Authors:  P A Drew; J T La Brooy; D J Shearman
Journal:  Gut       Date:  1984-06       Impact factor: 23.059

6.  Morphological study of antigen-sampling structures in the rat large intestine.

Authors:  P W Bland; D C Britton
Journal:  Infect Immun       Date:  1984-02       Impact factor: 3.441

7.  Secretory immunoglobulin A response to Shiga toxin in rabbits: kinetics of the initial mucosal immune response and inhibition of toxicity in vitro and in vivo.

Authors:  D F Keren; J E Brown; R A McDonald; J S Wassef
Journal:  Infect Immun       Date:  1989-07       Impact factor: 3.441

8.  Isolated Lymphoid Follicles are Dynamic Reservoirs for the Induction of Intestinal IgA.

Authors:  Kathryn A Knoop; Rodney D Newberry
Journal:  Front Immunol       Date:  2012-05-04       Impact factor: 7.561

  8 in total

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